Application of “smart” amine donors for rapid screening and scale-up of transaminase-mediated biotransformationsTools Gomm, Andrew and Grigoriou, Stylianos and Peel, Christopher and Ryan, James and Mujtaba, Nafees and Clarke, Thomas and Kulcinskaja, Evelina and O'Reilly, Elaine (2018) Application of “smart” amine donors for rapid screening and scale-up of transaminase-mediated biotransformations. European Journal of Organic Chemistry . ISSN 1099-0690
AbstractThe “smart” amine donors o‐xylylenediamine and cadaverine were employed for the rapid screening of a large ketone library and subsequent preparative‐scale synthesis of selected compounds using a commercially available amine transaminase, ATA256. The methodology enables both screening and preparative‐scale biotransformations to be performed with a single enzyme and simplifies the generation of sp3‐rich small‐molecule libraries.
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