An objective comparison of cell-tracking algorithms

Ulman, Vladimír, Maška, Martin, Magnusson, Klas E G, Ronneberger, Olaf, Haubold, Carsten, Harder, Nathalie, Matula, Pavel, Matula, Petr, Svoboda, David, Radojevic, Miroslav, Smal, Ihor, Rohr, Karl, Jaldén, Joakim, Blau, Helen M, Dzyubachyk, Oleh, Lelieveldt, Boudewijn, Xiao, Pengdong, Li, Yuexiang, Cho, Siu-Yeung, Dufour, Alexandre C, Olivo-Marin, Jean-Christophe, Reyes-Aldasoro, Constantino C, Solis-Lemus, Jose A, Bensch, Robert, Brox, Thomas, Stegmaier, Johannes, Mikut, Ralf, Wolf, Steffen, Hamprecht, Fred A, Esteves, Tiago, Quelhas, Pedro, Demirel, Ömer, Malmström, Lars, Jug, Florian, Tomancak, Pavel, Meijering, Erik, Muñoz-Barrutia, Arrate, Kozubek, Michal and Ortiz-de-Solorzano, Carlos (2017) An objective comparison of cell-tracking algorithms. Nature Methods, 14 (12). pp. 1141-1152. ISSN 1548-7091

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We present a combined report on the results of three editions of the Cell Tracking Challenge, an ongoing initiative aimed at promoting the development and objective evaluation of cell segmentation and tracking algorithms. With 21 participating algorithms and a data repository consisting of 13 data sets from various microscopy modalities, the challenge displays today's state-of-the-art methodology in the field. We analyzed the challenge results using performance measures for segmentation and tracking that rank all participating methods. We also analyzed the performance of all of the algorithms in terms of biological measures and practical usability. Although some methods scored high in all technical aspects, none obtained fully correct solutions. We found that methods that either take prior information into account using learning strategies or analyze cells in a global spatiotemporal video context performed better than other methods under the segmentation and tracking scenarios included in the challenge.

Item Type: Article
Additional Information: six months embargo
Keywords: Cell tracking; cell segmentation; Tracking algorithms
Schools/Departments: University of Nottingham Ningbo China > Faculty of Science and Engineering > Department of Electrical and Electronic Engineering
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Depositing User: Yu, Tiffany
Date Deposited: 10 Aug 2018 06:44
Last Modified: 10 Aug 2018 06:44

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