Microwave synthesis of novel methacrylate monomers designed to reduce biofilm formation to surfacesTools Dundas, Adam Alastair (2018) Microwave synthesis of novel methacrylate monomers designed to reduce biofilm formation to surfaces. PhD thesis, University of Nottingham.
AbstractRational design of biomaterials is hindered by the lack of quantitative structure-activity relationships (QSAR). Here we report the use of a QSAR to guide experimentation into a new chemical space; we predict and synthesize molecular structures for novel monomers that will reduce biofilm formation, and so identifying the lowest biofilm attachment polymer discovered to date. Cyclododecyl methacrylate was shown to reduce the formation of P. aeruginosa and P. mirabilis biofilms by up to 96 % and 97 % respectively compared to commercially available catheters. We believe that this is the first instance of a biomaterials screening program extending beyond the domain covered by the initial screen to predict a novel chemical entity with improved properties. This validates the QSAR approach for identifying polymers that resist biofilm formation beyond its chemical training domain.
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