Fulvestrant for the treatment of advanced breast cancer

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Blackburn, Sophie A., Parks, Ruth M. and Cheung, Kwok-Leung (2018) Fulvestrant for the treatment of advanced breast cancer. Expert Review of Anticancer Therapy, 18 (7). pp. 619-628. ISSN 1473-7140

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Abstract

Introduction: The current issues with endocrine therapy for treatment of advanced breast cancer include balance of efficacy of therapy versus tolerability as well as hormone resistance. The efficacy of fulvestrant, a selective oestrogen receptor degrader (SERD), has been demonstrated in hormone receptor positive patients previously untreated or treated with hormonal therapy.

Areas covered: This article discusses the journey of fulvestrant licensing, its efficacy in combination with other endocrine therapies and the future role it may have within breast cancer treatment.

Expert commentary: Within phase III trials, fulvestrant has demonstrated equivalent or improved clinical efficacy when compared with established endocrine agents. In the recent decade, fulvestrant has achieved licensing as a second line agent in non-operative advanced breast cancer at initially 250mg, increasing to 500mg. Presently, fulvestrant is licensed globally as first line endocrine management for advanced breast cancer in post-menopausal women. Early combination trials of fulvestrant and cyclin dependent kinase 4/6 inhibitors have demonstrated good clinical efficacy with improved progression free survival when compared to fulvestrant alone.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/932673
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Anticancer Therapy on 11 May 2018, available online: http://www.tandfonline.com/10.1080/14737140.2018.1473038
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine
Identification Number: https://doi.org/10.1080/14737140.2018.1473038
Depositing User: Eprints, Support
Date Deposited: 28 Jun 2018 15:10
Last Modified: 04 May 2020 19:36
URI: https://eprints.nottingham.ac.uk/id/eprint/52665

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