Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printingTools Lovato, Tatiana, Taresco, Vincenzo, Alazzo, Ali, Sansone, Catarina, Stolnik, Snjezana, Alexander, Cameron and Conte, Claudia (2018) Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing. Journal of Materials Chemistry B . ISSN 2050-7518 (In Press) Full text not available from this repository.AbstractHere we describe a rapid inkjet formulation method for screening newly-synthesised cationic materials for siRNA delivery into cancer cells. Reduction responsive oligo-β-aminoesters were prepared and evaluated for their ability to condense siRNA into polyplexes through a fast inkjet printing method. A direct relationship between the oligomer structures and charge densities, and the final cell response in terms of uptake rate and transfection efficacy, was found. The oligo-β-aminoesters were well-tolerated by the cancer cells, compared to conventional cationic polymers so far employed in gene delivery, and were as active in silencing of a representative luciferase gene.
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