Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printingTools Lovato, Tatiana and Taresco, Vincenzo and Alazzo, Ali and Sansone, Catarina and Stolnik, Snjezana and Alexander, Cameron and Conte, Claudia (2018) Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing. Journal of Materials Chemistry B . ISSN 2050-7518 (In Press) Full text not available from this repository.AbstractHere we describe a rapid inkjet formulation method for screening newly-synthesised cationic materials for siRNA delivery into cancer cells. Reduction responsive oligo-β-aminoesters were prepared and evaluated for their ability to condense siRNA into polyplexes through a fast inkjet printing method. A direct relationship between the oligomer structures and charge densities, and the final cell response in terms of uptake rate and transfection efficacy, was found. The oligo-β-aminoesters were well-tolerated by the cancer cells, compared to conventional cationic polymers so far employed in gene delivery, and were as active in silencing of a representative luciferase gene.
Actions (Archive Staff Only)
|
From the 1st Oct 2021, the research publications and student eTheses of University of Nottingham Ningbo China authors will be handled through the UNNC Research Information System (RIS).
If you are a UNNC author, please login to the UNNC RIS in order to deposit articles and etheses after this date, or contact UNNCRIS@nottingham.edu.cn if you have any enquiries in regard to this change.
If you are a UNNC author, please login to the UNNC RIS in order to deposit articles and etheses after this date, or contact UNNCRIS@nottingham.edu.cn if you have any enquiries in regard to this change.
Tools
Tools
