Monosodium urate crystal deposits are common in asymptomatic sons of people with gout: The Sons of gout study

Abhishek, Abhishek, Courtney, Philip, Jenkins, Wendy, Sandoval-Plata, Gabriela, Jones, Adrian, Zhang, Weiya and Doherty, Michael (2018) Monosodium urate crystal deposits are common in asymptomatic sons of people with gout: The Sons of gout study. Arthritis & Rheumatology . ISSN 2326-5205

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Objective To estimate the prevalence and distribution of asymptomatic monosodium urate (MSU) crystal deposition in sons of people with gout.

Method People with gout were mailed an explanatory letter enclosing a postage-paid study-pack to mail to their son(s) ≥20 years old. Sons interested in participating returned a reply-slip and underwent telephone screening. Subsequently they attended a study-visit for blood and urine collection, and musculoskeletal ultrasonography performed blind to serum urate (SU). Images were assessed for double contour sign (DCS), intra-articular or intra-tendinous aggregates/tophi, effusion and power Doppler. Logistic regression was used to examine associations.

Results 131 sons (mean age 43.80 years, body mass index 27.10 kg/m2) completed assessments. 64.1% had SU ≥6 mg/dl, and 29.8% had either DCS or intra-articular aggregates/tophi in ≥1 joint. All participants with MSU deposition had involvement of either 1st metatarsophalangeal joint. 21.4% had intra-tendinous aggregates, and these associated with intra-articular MSU crystal deposits (aOR (95%CI) 2.96(1.17-7.49)). No participant had MSU crystal deposition at SU ≤5 mg/dl, and 24.2% participants with SU between 5-6 mg/dl had ultrasonographic MSU deposition. MSU crystal deposition associated with increasing SU (aOR (95%CI) 1.61(1.10-2.36) for each 1 mg/dl increase).

Conclusion Asymptomatic sons of people with gout frequently have hyperuricemia and MSU crystal deposits. In this study MSU crystal deposits were present in participants with SU >5 mg/dl. Evaluation of people without a family history of gout is needed to confirm if the threshold for MSU crystal deposition is also lower in the general population.

Item Type: Article
Keywords: Gout; Crystal arthritis; Ultrasonography; Hyperuricemia; Asymptomatic gout
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Rheumatology, Orthopaedics and Dermatology
Identification Number:
Depositing User: Abhishek, Abhishek
Date Deposited: 01 Jun 2018 08:09
Last Modified: 04 May 2020 19:37

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