How to characterize the function of a brain region

Genon, Sarah, Reid, Andrew, Langner, Robert, Amunts, Katrin and Eickhoff, Simon B. (2018) How to characterize the function of a brain region. Trends in Cognitive Sciences, 22 (4). pp. 350-364. ISSN 1879-307X

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Many brain regions have been defined, but a comprehensive formalization of each region’s function in relation to human behavior is still lacking. Current knowledge comes from various fields, which have diverse conceptions of ‘functions’. We briefly review these fields and outline how the heterogeneity of associations could be harnessed to disclose the computational function of any region. Aggregating activation data from neuroimaging studies allows us to characterize the functional engagement of a region across a range of experimental conditions. Furthermore, large-sample data can disclose covariation between brain region features and ecological behavioral phenotyping. Combining these two approaches opens a new perspective to determine the behavioral associations of a brain region, and hence its function and broader role within large-scale functional networks.

Item Type: Article
Keywords: Functional specialization; Data-driven; Brain mapping; MRI; Neurosynth; BrainMap
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Psychology
Identification Number:
Depositing User: Reid, Andrew
Date Deposited: 24 Apr 2018 08:18
Last Modified: 04 May 2020 19:34

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