Ventromedial prefrontal volume in adolescence predicts hyperactive/inattentive symptoms in adulthood

Albaugh, Matthew, Ivanova, Masha, Chaarani, Bader, Orr, Catherine, Allgaier, Nicholas, Althoff, Robert, D'Alberto, Nicholas, Hudson, Kelse, Mackey, Scott, Spechler, Philip, Banaschewski, Tobias, Bokde, Arun, Bromberg, Uli, Cattrell, Anna, J.Conrod, Patricia and Gowland, Penny (2018) Ventromedial prefrontal volume in adolescence predicts hyperactive/inattentive symptoms in adulthood. Cerebral Cortex, 29 (5). pp. 1866-1874. ISSN 1460-2199

PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Download (1MB) | Preview


Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1,104 participants (M = 14.52 yrs, SD = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = -.274, p < .001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms.

Item Type: Article
Additional Information: 37 authors in total. This is a pre-copyedited, author-produced version of an article accepted for publication in Cerebral Cortex following peer review. The version of record is available online at:
Keywords: attention-deficit/hyperactivity disorder, neuroimaging, ventromedial prefrontal cortex
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Physics and Astronomy
Identification Number:
Depositing User: Eprints, Support
Date Deposited: 27 Feb 2018 09:59
Last Modified: 16 May 2019 14:07

Actions (Archive Staff Only)

Edit View Edit View