MDM2 expression in the progression of Barrett’s oesophagus

Robinson, Leora, Ilyas, Mohammad, Ragunath, Krish, Card, Timothy R., Abradu-Berchie, Berice and Kaye, Philip (2018) MDM2 expression in the progression of Barrett’s oesophagus. Histopathology, 72 (7). pp. 1230-1233. ISSN 1365-2559

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Barrett's oesophagus (BO) is the main precursor for oesophageal adenocarcinoma (OAC), and dysplasia arising within it is the standard marker used to predict risk of malignant progression. However, dysplasia diagnosis is subject to a significant amount of interobserver variation. Biomarkers may aid the diagnosis of dysplasia and may help predict the risk of progression to OAC. Abnormal expression of p53 can be reproducibly detected by immunohistochemistry (IHC) and it is an effective marker of risk of OAC1. There is however still a need for additional early stage markers.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Robinson, L., Ilyas, M., Ragunath, K., Card, T., Abradu-Berchie, B. and Kaye, P. (), MDM2 Expression in the Progression of Barrett's Oesophagus. Histopathology. Accepted Author Manuscript. doi:10.1111/his.13480 , which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: Barret’s oesophagus; MDM2; p53; Dysplasia
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Nottingham Digestive Diseases Centre
Identification Number:
Depositing User: Brueton, Kim
Date Deposited: 07 Feb 2018 13:12
Last Modified: 04 May 2020 19:44

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