Study-based registers of randomized controlled trials: starting a systematic review with data extraction or meta-analysis

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Shokraneh, Farhad and Adams, Clive E. (2017) Study-based registers of randomized controlled trials: starting a systematic review with data extraction or meta-analysis. Bioimpacts, 7 (4). pp. 209-217. ISSN 2228-5652

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Abstract

Introduction: Despite years of use of study-based registers for storing reports of randomized controlled trials (RCTs), the methodology used in developing such registers/databases has not been documented. Such registers are integral to the process of scientific reviewing. We document and discuss methodological aspects of the development and use of study-based registers. Although the content is focused on the study-based register of randomized/controlled clinical trials, this work applies to developers of databases of all sorts of studies related to the human, animals, cells, genes, and molecules.

Methods: We describe necessity, rationale, and steps for the development, utilization and maintenance of study-based registers as well as the challenges and gains for the organizations supporting systematic reviews of the published and unpublished literature.

Conclusion: The ultimate goal of having a study-based register is to facilitate efficient production of systematic reviews providing rapid, yet accurate, evidence for the decision-makers. We argue that moving towards study-based registers is an inevitable welcome direction and that infrastructures are ready for such movement.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/887815
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine
Identification Number: 10.15171/bi.2017.25
Depositing User: Eprints, Support
Date Deposited: 08 Jan 2018 13:42
Last Modified: 04 May 2020 19:12
URI: https://eprints.nottingham.ac.uk/id/eprint/48979

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