Restoring mucosal barrier function and modifying macrophage phenotype with an extracellular matrix hydrogel: potential therapy for ulcerative colitisTools Keane, Timothy J. and Dziki, Jenna and Sobieski, Eric and Smoulder, Adam and Castleton, Arthur A and Turner, Neill J. and White, Lisa J. and Badylak, Stephen F. (2017) Restoring mucosal barrier function and modifying macrophage phenotype with an extracellular matrix hydrogel: potential therapy for ulcerative colitis. Journal of Crohn's and Colitis, 11 (3). 360 -368. ISSN 1873-9946 Full text not available from this repository.AbstractBackground & Aims: Despite advances in therapeutic options, more than half of all patients with ulcerative colitis (UC) do not achieve long-term remission, many require colectomy, and the disease still has a marked negative impact on quality of life. Extracellular matrix (ECM) bioscaffolds facilitate the functional repair of many soft tissues by mechanisms that include mitigation of pro-inflammatory macrophage phenotype and mobilization of endogenous stem/progenitor cells. The aim of the present study was to determine if an ECM hydrogel therapy could influence outcomes in an inducible rodent model of UC.
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