Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsiaTools Smith-Jackson, Kate, Hentschke, Marta, Poli-de-Figueiredo, Carlos, Pinheiro da Costa, Bartira, Broughton Pipkin, Fiona, Czajka, Anna and Mistry, Hiten D. (2015) Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia. Placenta, 36 (5). pp. 607-610. ISSN 1532-3102 Full text not available from this repository.AbstractCaveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/ iNOS in normotensive control (n=24) and pre-eclamptic pregnancies (n=19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P<0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P=0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation.
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