Expression of voltage-dependent potassium channels in first trimester human placentae

Mistry, Hiten D., Kurlak, L.O., Whitley, Guy S., Cartwright, Judith E., Broughton Pipkin, Fiona and Tribe, Rachel M. (2014) Expression of voltage-dependent potassium channels in first trimester human placentae. Placenta, 35 (5). pp. 337-340. ISSN 1532-3102

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Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (Kv7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at <10 weeks’ (early TOP) and >10 weeks’ (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P=0.022). This novel study reports mRNA and protein expression of Kv7 channels in first trimester placentae.

Item Type: Article
Keywords: Potassium channel, Placenta, Early pregnancy, KCNQ, KCNE
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Child Health, Obstetrics and Gynaecology
Identification Number:
Depositing User: Mistry, Hiten
Date Deposited: 21 Jul 2017 10:02
Last Modified: 12 Oct 2017 23:34

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