Total synthesis of the cyclic dodecapeptides wewakazole and wewakazole BTools Inman, Martyn, Dexter, Hannah L. and Moody, Christopher J. (2017) Total synthesis of the cyclic dodecapeptides wewakazole and wewakazole B. Organic Letters, 19 (13). pp. 3454-3457. ISSN 1523-7052 Full text not available from this repository.
Official URL: http://pubs.acs.org/doi/abs/10.1021/acs.orglett.7b01393
AbstractThe cyclic dodecapeptides wewakazole and wewakazole B have been synthesized by a divergent strategy via a common tris-proline containing oxazole octapeptide and two separate bisoxazole containing tetrapeptide units, followed by peptide coupling and macrocyclization. The three oxazole amino acid fragments are readily accessible by rhodium(II)-catalysed amide N–H insertion of diazocarbonyl compounds, or by the cycloaddition of rhodium carbenoids with nitriles.
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