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Jollans, Lee and Zhipeng, Cao and Icke, Ilknur and Greene, Ciara and Kelly, Clare and Banaschewski, Tobias and Bokde, Arun L. W. and Bromberg, Uli and Büchel, Christian and Cattrell, Anna and Conrod, Patricia J. and Desrivières, Sylvane and Flor, Herta and Frouin, Vincent and Gallinat, Jürgen and Garavan, Hugh and Gowland, Penny and Heinz, Andreas and Ittermann, Bernd and Martinot, Jean-Luc and Artiges, Eric and Nees, Frauke and Papadopoulos Orfanos, Dimitri and Paus, Tomáš and Smolka, Michael N. and Walter, Henrik and Schumann, Gunter and Whelan, Robert (2016) Ventral striatum connectivity during reward anticipation in adolescent smokers. Developmental Neuropsychology, 41 (1-2). pp. 6-21. ISSN 1532-6942

Abstract

Substance misusers, including adolescent smokers, often have reduced reward system activity during processing of non-drug rewards. Using a psychophysiological interaction approach, we examined functional connectivity with the ventral striatum during reward anticipation in a large (N = 206) sample of adolescent smokers. Increased smoking frequency was associated with (1) increased connectivity with regions involved in saliency and valuation, including the orbitofrontal cortex and (2) reduced connectivity between the ventral striatum and regions associated with inhibition and risk aversion, including the right inferior frontal gyrus. These results demonstrate that functional connectivity during reward processing is relevant to adolescent addiction.

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