Ventral striatum connectivity during reward anticipation in adolescent smokers

Jollans, Lee, Zhipeng, Cao, Icke, Ilknur, Greene, Ciara, Kelly, Clare, Banaschewski, Tobias, Bokde, Arun L. W., Bromberg, Uli, Büchel, Christian, Cattrell, Anna, Conrod, Patricia J., Desrivières, Sylvane, Flor, Herta, Frouin, Vincent, Gallinat, Jürgen, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Martinot, Jean-Luc, Artiges, Eric, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Paus, Tomáš, Smolka, Michael N., Walter, Henrik, Schumann, Gunter and Whelan, Robert (2016) Ventral striatum connectivity during reward anticipation in adolescent smokers. Developmental Neuropsychology, 41 (1-2). pp. 6-21. ISSN 1532-6942

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Substance misusers, including adolescent smokers, often have reduced reward system activity during processing of non-drug rewards. Using a psychophysiological interaction approach, we examined functional connectivity with the ventral striatum during reward anticipation in a large (N = 206) sample of adolescent smokers. Increased smoking frequency was associated with (1) increased connectivity with regions involved in saliency and valuation, including the orbitofrontal cortex and (2) reduced connectivity between the ventral striatum and regions associated with inhibition and risk aversion, including the right inferior frontal gyrus. These results demonstrate that functional connectivity during reward processing is relevant to adolescent addiction.

Item Type: Article
Additional Information: Date of acceptance is estimated. // This is an Accepted Manuscript of an article published by Taylor & Francis in Developmental Neuropsychology on 13 April 2016, available online:
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Physics and Astronomy
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Depositing User: Eprints, Support
Date Deposited: 09 May 2017 08:55
Last Modified: 04 May 2020 17:46

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