Comorbities and medications of patients with chronic hepatitis C under specialist care in the UK

Hudson, Benjamin, Walker, Alex J. and Irving, William L. (2017) Comorbities and medications of patients with chronic hepatitis C under specialist care in the UK. Journal of Medical Virology, 89 (12). pp. 2158-2164. ISSN 1096-9071

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Designing services with the capacity and expertise to meet the needs of the chronic hepatitis C (CHC) population in the era of direct acting antivirals (DAAs), and widening access to such treatments, requires detailed understanding of the characteristics and healthcare needs of the existing patient population. In this retrospective analysis of data from the National HCV Research UK Biobank between March 2012–October 2014 the characteristics of the CHC population currently under specialist care in the UK were evaluated – with specific focus upon use of medications, adverse lifestyle choices, and comorbidities.. Demographic data, risk factors for CHC acquisition, HCV genotype, liver disease status, lifestyle factors, comorbidities, and medication classes were collected. Data were analysed by history of injecting drug use (IDU), age, and severity of liver disease. 6278 patients (70.5% white; median age, 52 years) from 59 UK specialist centres were included; 59.1% of patients had acquired HCV through IDU. The prevalence of adverse lifestyle factors was significantly lower in non-IDU compared with previous IDU or recent IDU patients. Depression was common in the previous (50.8%) and recent IDU (68.1%) groups, compared with 27.6% in non-IDU patients. Cirrhosis was common (23.6%), and prevalence increased with age. We describe a heterogeneous, polymorbid, and aging population of CHC patients in secondary care, and demonstrate underrepresentation of injecting drug users within the current system. The implications of this present significant challenges to physicians and healthcare commissioners in designing services which are fit for purpose in the DAA era.

Item Type: Article
Keywords: Chronic hepatitis C, Direct-acting antivirals, Drug–drug interaction, Hepatitis C virus, Injecting drug use
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Nottingham Digestive Diseases Centre
Identification Number:
Depositing User: Eprints, Support
Date Deposited: 20 Apr 2017 10:05
Last Modified: 04 May 2020 19:02

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