Protein–like fully reversible tetramerisation and super-association of an aminocelluloseTools Nikolajski, Melanie, Adams, Gary G., Gillis, Richard B., Besong, David Tabot, Rowe, Arthur J., Heinze, Thomas and Harding, Stephen E. (2014) Protein–like fully reversible tetramerisation and super-association of an aminocellulose. Scientific Reports, 4 . 3861/1-3861/5. ISSN 2045-2322 Full text not available from this repository.
Official URL: https://doi.org/10.1038/srep03861
AbstractUnusual protein-like, partially reversible associative behaviour has recently been observed in solutions of the water soluble carbohydrates known as 6-deoxy-6-(v-aminoalkyl)aminocelluloses, which produce controllable self-assembling films for enzyme immobilisation and other biotechnological applications. Now, for the first time, we have found a fully reversible self-association (tetramerisation) within this family of polysaccharides. Remarkably these carbohydrate tetramers are then seen to associate further in a regular way into supra-molecular complexes. Fully reversible oligomerisation has been hitherto completely unknown for carbohydrates and instead resembles in some respects the assembly of polypeptides and proteins like haemoglobin and its sickle cell mutation. Our traditional perceptions as to what might be considered ‘‘protein-like’’ and what might be considered as ‘‘carbohydrate-like’’ behaviour may need to be rendered more flexible, at least as far as interaction phenomena are concerned.
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