Impact of a common genetic variation associated with putamen volume on neural mechanisms of ADHDTools Xu, Bing and Jia, Tianye and Macare, Christine and Banaschewski, Tobias and Bokde, Arun L.W. and Bromberg, Uli and Büchel, Christian and Cattrell, Anna and Conrod, Patricia J. and Flor, Herta and Frouin, Vincent and Gallinat, Jürgen and Garavan, Hugh and Gowland, Penny A. and Heinz, Andreas and Ittermann, Bernd and Martinot, Jean-Luc and Martinot, Marie-Laure Paillère and Nees, Frauke and Orfanos, Dimitri Papadopoulos and Paus, Tomáš and Poustka, Luise and Smolka, Michael N. and Walter, Henrik and Whelan, Robert and Schumann, Gunter and Desrivières, Sylvane (2010) Impact of a common genetic variation associated with putamen volume on neural mechanisms of ADHD. Journal of the American Academy of Child and Adolescent Psychiatry . ISSN 1527-5418 (In Press) Full text not available from this repository.AbstractObjective: In a recent genome-wide association study of subcortical brain volumes, we have identified common genetic variation at rs945270 as having the strongest effect on putamen volume, a brain measure linked to familial risk for attentiondeficit/hyperactivity disorder (ADHD). To determine whether rs945270 is a genetic determinant of ADHD, we now explored it impacts on ADHD related symptoms and on neural mechanisms of ADHD, such as response inhibition and reward sensitivity.
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