Functional phosphatome requirement for protein homeostasis, networked mitochondria, and sarcomere structure in C. elegans muscleTools Lehmann, Susann and Bass, Joseph J. and Barratt, Thomas F. and Ali, Mohammed Z. and Szewczyk, Nathaniel J. (2017) Functional phosphatome requirement for protein homeostasis, networked mitochondria, and sarcomere structure in C. elegans muscle. Journal of Cachexia, Sarcopenia and Muscle, 8 (4). pp. 660-672. ISSN 2190-6009 Full text not available from this repository.AbstractBackground: Skeletal muscle is central to locomotion and metabolic homeostasis. The laboratory worm C. elegans has been developed into a genomic model for assessing the genes and signals that regulate muscle development and protein degradation. Past work has identified a receptor tyrosine kinase signalling network that combinatorially controls autophagy, nerve signal to muscle to oppose proteasome based degradation, and extracellular matrix based signals that control calpain and caspase activation. The last two discoveries were enabled by following up results from a functional genomic screen of known regulators of muscle. Recently, a screen of the kinome requirement for muscle homeostasis identified roughly 40% of kinases as required for C. elegans muscle health; 80 have identified human orthologues and 53 are known to be expressed in skeletal muscle. To complement this kinome screen, here we screen most of the phosphatases in C. elegans.
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