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Devescovi, Giulia, Kojic, Milan, Covaceuszach, Sonia, Cámara, Miguel, Williams, Paul, Bertani, Iris, Subramoni, Sujatha and Venturi, Vittorio (2017) Negative regulation of violacein biosynthesis in Chromobacterium violaceum. Frontiers in Microbiology, 8 . 349/1-349/37. ISSN 1664-302X

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Abstract

In Chromobacteium violaceum, the purple pigment violacein is under positive regulation by the N-acylhomoserine lactone CviI/R quorum sensing system and negative regulation by an uncharacterized putative repressor. In this study we report that the biosynthesis of violacein is negatively controlled by a novel repressor protein, VioS. The violacein operon is regulated negatively by VioS and positively by the CviI/R system in both C. violaceum and in a heterologous Escherichia coli genetic background. VioS does not regulate the CviI/R system and apart from violacein, VioS and quorum sensing regulate other phenotypes antagonistically. Quorum sensing regulated phenotypes in C. violaceum are therefore further regulated providing an additional level of control.

Item Type:	Article
RIS ID:	https://nottingham-repository.worktribe.com/output/845155
Keywords:	Chromobacterium violaceum, VioS, CviI/R quorum sensing, regulation, Violacein, Chitinase activity, Protease activity
Schools/Departments:	University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences
Identification Number:	https://doi.org/10.3389/fmicb.2017.00349
Depositing User:	Eprints, Support
Date Deposited:	20 Feb 2017 13:41
Last Modified:	04 May 2020 18:34
URI:	https://eprints.nottingham.ac.uk/id/eprint/40663

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