The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover

Zhou, Lian, Zhang, Lian-Hui, Cámara, Miguel and He, Ya-Wen (2017) The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover. Trends in Microbiology, 25 (4). pp. 293-303. ISSN 1878-4380

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The diffusible signaling factor (DSF)-based quorum sensing (QS) system has emerged as a widely conserved cell–cell communication mechanism in Gram-negative bacteria. Typically, signals from the DSF family are cis-2-unsaturated fatty acids which regulate diverse biological functions. Recently, substantial progress has been made on the characterization of new members of this family of signals. There have also been new developments in the understanding of the biosynthesis of these molecules where dual enzymatic activities of the DSF synthase and the use of various substrates have been described. The recent discovery of a naturally occurring DSF turnover mechanism and its regulation provides a new dimension in our understanding of how DSF-dependent microorganisms modulate virulence gene expression in response to changes in the surrounding environment.

Item Type: Article
Keywords: Quorum sensing, DSF, Biosynthesis, Naturally occurring signal turnover, Xanthomonas
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences
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Depositing User: Eprints, Support
Date Deposited: 09 Feb 2017 13:07
Last Modified: 04 May 2020 18:40

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