Recent progress in translational research on neurovascular and neurodegenerative disordersTools Demuth, Hans-Ulrich, Dijkhuizen, Rick M., Farr, Tracy D., Gelderblom, Mathias, Horsburgh, Karen, Iadecola, Constantino, Mcleod, Damian D., Michalski, Dominik, Murphy, Tim H., Orbe, Josuna, Otte, Willem M., Petzold, Gabor C., Plesnila, Nikolaus, Reiser, Georg, Reymann, Klaus G., Rueger, Maria A., Saur, Dorothee, Savitz, Sean I., Schilling, Stephan, Spratt, Neil J., Turner, Renée J., Vemuganti, Raghu, Vivien, Denis, Yepes, Manuel, Zille, Marietta and Boltze, Johannes (2017) Recent progress in translational research on neurovascular and neurodegenerative disorders. Restorative Neurology and Neuroscience, 35 (1). pp. 87-103. ISSN 1878-3627 Full text not available from this repository.AbstractThe already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundamental progress in evidence-based medicine to improve the patient’s outcome. This has been paralleled by a swift increase in our understanding of pathomechanisms underlying many neurovascular diseases and most prevalent forms of dementia. Taken together, these current advances offer the potential to overcome almost two decades of marginally successful translational research on stroke and dementia, thereby spurring the entire field of translational neuroscience. Moreover, they may also pave the way for the renaissance of classical neuroprotective paradigms.
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