Ban, Lu, West, Joe, Abdul Sultan, Alyshah, Dhalwani, Nafeesa N., Ludvigsson, Jonas F. and Tata, Laila J.
(2014)
Limited risks of major congenital anomalies in children of mothers with coeliac disease: a population-based cohort study.
BJOG: An International Journal of Obstetrics & Gynaecology, 122
(13).
pp. 1833-1841.
ISSN 1471-0528
Full text not available from this repository.
Abstract
Objective: To examine major congenital anomaly (CA) risks in children of mothers with coeliac disease (CD) compared with mothers without CD.
Design: Population-based cohort study.
Setting: Linked maternal–child medical records from a large primary care database from the UK.
Population: A total of 562 332 live singletons of mothers with and without CD in 1990–2013.
Methods: We calculated the absolute major CA risks in children whose mothers had CD, and whether this was diagnosed or undiagnosed before childbirth. Logistic regression with a generalised estimating equation was used to estimate adjusted odds ratios (aORs) with 95% confidence intervals (95% CIs) for CAs associated with CD.
Main outcome measures: Fourteen system-specific major CA groups classified according to the European Surveillance of Congenital Anomalies and neural tube defects (NTDs).
Results: Major CA risk in 1880 children of mothers with CD was 293 per 10 000 liveborn singletons, similar to the risk in those without CD (282; aOR 0.98, 95% CI 0.74–1.30). The risk was slightly higher in 971 children, whose mothers were undiagnosed (350; aOR 1.14, 95% CI 0.79–1.64), than in 909 children whose mothers were diagnosed (231; aOR 0.80, 95% CI 0.52–1.24). There was a three-fold increase in nervous system anomalies in the children of mothers with undiagnosed CD (aOR 2.98, 95% CI 1.06–8.33, based on five exposed cases and one had an NTD), and these women were all diagnosed with CD at least 4 years after their children were born.
Conclusions: There was no statistically significant increase in risk of major CAs in children of mothers with coeliac disease overall, compared with the general population.
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