• Login
• Admin

Otete, Harmony E., Orton, Elizabeth, Fleming, Kate M. and West, Joe (2016) Alcohol-attributable healthcare attendances up to 10 years prior to diagnosis of alcoholic cirrhosis: a population based case-control study. Liver international, 36 (4). pp. 538-546. ISSN 1478-3231

Full text not available from this repository.

Abstract

BACKGROUND & AIMS:

Cirrhosis because of alcohol could be avoided if drinking behaviour could be altered earlier in the disease course. Our aim was to quantify the burden of morbidities in patients prior to alcoholic cirrhosis diagnosis, as this may inform the earlier identification of people at high risk for targeted interventions.

METHODS:

We carried out a case-control study using 2479 incident cases of alcoholic cirrhosis and 24 790 controls identified from 357 primary and secondary care centres in England. We assessed the prevalence of morbidities that are partly attributable to alcohol (namely malignant neoplasms, diabetes, epilepsy, injuries, cardiovascular and digestive diseases) prior to alcoholic cirrhosis diagnosis. We compared prevalence in cases to the control population and used logistic regression to derive odds ratios (95% CI).

RESULTS:

Fifty-eight per cent of cases compared to 29% of controls had had at least one alcohol-attributable condition before cirrhosis diagnosis. The most frequent conditions (proportion in cases vs. controls) were intentional injuries (35.9% vs. 11.9%) and cardiovascular diseases (23.2% vs. 15.6%), followed by diabetes (12.8% vs. 5.3%), digestive diseases (6.1% vs. 1.2%) and epilepsy (5.0% vs. 1.1%). The strongest association with alcoholic cirrhosis was found for digestive diseases [OR 5.4 (4.4-6.7)], epilepsy [OR: 4.4 (3.5-5.5)] and injuries [OR: 4.0 (3.7-4.4)] particularly among those aged 18-44 years.

CONCLUSION:

These data highlight the high burden of other alcohol-attributable conditions in patients prior to alcoholic cirrhosis diagnosis. Reviewing those consistently presenting with any of these conditions more closely could help practitioners reduce/avoid the long-term consequences of development of alcoholic liver disease.

Item Type:	Article
RIS ID:	https://nottingham-repository.worktribe.com/output/783095
Additional Information:	This is the peer reviewed version of the following article: Alcohol-attributable healthcare attendances up to 10 years prior to diagnosis of alcoholic cirrhosis: a population based case-control study, Harmony E. Otete, Elizabeth Orton, Kate M. Fleming, Joe West, Liver Int. 2016; 36: 538–546, which has been published in final form at doi:10.1111/liv.13002. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords:	alcoholic liver disease; comorbidities; early identification; healthcare utilization; intervention
Schools/Departments:	University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Primary Care University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Epidemiology and Public Health
Identification Number:	https://doi.org/10.1111/liv.13002
Depositing User:	Otete, Harmony
Date Deposited:	04 Nov 2016 13:44
Last Modified:	04 May 2020 17:44
URI:	https://eprints.nottingham.ac.uk/id/eprint/38488

Actions (Archive Staff Only)

Edit View