%PDF-1.4
%
185 0 obj
<>
endobj
173 0 obj
<>
endobj
172 0 obj
<>stream
Arbortext Advanced Print Publisher 10.0.1465/W Unicode
2016-07-21T04:56:33-07:00
2016-07-16T12:15:08+05:30
2016-07-21T04:56:33-07:00
application/pdf
doi:;
untitled
Acrobat Distiller 8.1.0 (Windows)
uuid:d9bb158e-583d-4251-acb5-0fdd2fce0d41
uuid:46f19c35-1dd2-11b2-0a00-1e0058798aff
http://dx.doi.org/
2016-07-16
false
http://bmjopen.bmj.com
2016-07-16
true
http://bmjopen.bmj.com
endstream
endobj
186 0 obj
<>
endobj
111 0 obj
<>
endobj
169 0 obj
<>
endobj
171 0 obj
<>
endobj
187 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/Properties<>/Shading<>/XObject<>>>/Rotate 0/Thumb 120 0 R/Type/Page>>
endobj
1 0 obj
<>/Font<>/ProcSet[/PDF/Text/ImageB]/Properties<>/XObject<>>>/Rotate 0/Thumb 121 0 R/Type/Page>>
endobj
15 0 obj
<>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/Rotate 0/Thumb 122 0 R/Type/Page>>
endobj
29 0 obj
<>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/Rotate 0/Thumb 123 0 R/Type/Page>>
endobj
47 0 obj
<>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/Rotate 0/Thumb 124 0 R/Type/Page>>
endobj
83 0 obj
<>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/Rotate 0/Thumb 125 0 R/Type/Page>>
endobj
467 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
498 0 obj
[503 0 R 504 0 R 505 0 R 506 0 R 507 0 R 508 0 R 509 0 R 510 0 R 511 0 R 512 0 R]
endobj
499 0 obj
<>stream
q
61.5 0 0 38.75 103.25 714.25 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
15 0 0 15 184 722.99997 Tm
(children: a systematic review)Tj
0 1 TD
(Invasiveness of pharmacokinetic studies in)Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 184 700 Tm
(Mohammed I Altamimi, Imti Choonara and Helen Sammons)Tj
ET
BT
/T1_1 1 Tf
12 0 0 12 184 663.99997 Tm
(doi: 10.1136/bmjopen-2015-010484)Tj
10 0 0 10 234.02002 676 Tm
(2016 6: )Tj
/T1_2 1 Tf
-5.002 0 Td
(BMJ Open\240)Tj
ET
84 650 m
511 650 l
0 0 m
S
BT
ET
BT
/T1_1 1 Tf
10 0 0 10 394.60901 615.99997 Tm
( )Tj
0 0 1 rg
/T1_0 1 Tf
-21.0609 0 Td
(http://bmjopen.bmj.com/content/6/7/e010484)Tj
0 g
/T1_1 1 Tf
T*
(Updated information and services can be found at: )Tj
ET
84 602 m
511 602 l
0 0 m
S
BT
ET
BT
/T1_2 1 Tf
10 0 0 10 184 574 Tm
(These include:)Tj
ET
BT
/T1_0 1 Tf
12 0 0 12 99.30817 554 Tm
(References)Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 421.84915 545.99997 Tm
( )Tj
0 0 1 rg
-2.72401 0 Td
(#BIBL)Tj
/T1_0 1 Tf
-21.06091 0 Td
(http://bmjopen.bmj.com/content/6/7/e010484)Tj
0 g
/T1_1 1 Tf
T*
(This article cites 24 articles, 4 of which you can access for free at: )Tj
ET
BT
/T1_0 1 Tf
12 0 0 12 87.96826 526 Tm
(Open Access)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
10 0 0 10 286.80978 477.99985 Tm
(http://creativecommons.org/licenses/by-nc/4.0/)Tj
0 g
-10.28098 0 Td
(non-commercial. See: )Tj
T*
(provided the original work is properly cited and the use is)Tj
0 1.00001 TD
(non-commercially, and license their derivative works on different terms,\
)Tj
0 1 TD
(permits others to distribute, remix, adapt, build upon this work)Tj
T*
(Commons Attribution Non Commercial \(CC BY-NC 4.0\) license, which )Tj
0 1.00001 TD
(This is an Open Access article distributed in accordance with the Creati\
ve)Tj
ET
BT
/T1_0 1 Tf
12 0 0 12 119.29999 445.99997 Tm
(service)Tj
-2.83299 1 Td
(Email alerting)Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 184 449.99997 Tm
(box at the top right corner of the online article. )Tj
0 1 TD
(Receive free email alerts when new articles cite this article. Sign up i\
n the)Tj
ET
84 423 m
511 423 l
0 0 m
S
BT
ET
BT
/T1_0 1 Tf
12 0 0 12 95.98444 384.99997 Tm
(Collections)Tj
3.00099 1 Td
(Topic)Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 184 399 Tm
(Articles on similar topics can be found in the following collections )Tj
ET
BT
/T1_1 1 Tf
10 0 0 10 334.61984 369.99997 Tm
( \(360\))Tj
0 0 1 rg
-14.06198 0 Td
(Pharmacology and therapeutics)Tj
0 g
4.946 1 Td
( \(453\))Tj
0 0 1 rg
-4.946 0 Td
(Paediatrics)Tj
ET
84 356 m
511 356 l
0 0 m
S
BT
ET
BT
0 g
/T1_0 1 Tf
12 0 0 12 84 335 Tm
(Notes)Tj
ET
84 182 m
511 182 l
0 0 m
S
BT
ET
BT
0 0 1 rg
/T1_0 1 Tf
10 0 0 10 84 143.99997 Tm
(http://group.bmj.com/group/rights-licensing/permissions)Tj
0 g
/T1_1 1 Tf
T*
(To request permissions go to:)Tj
ET
BT
0 0 1 rg
/T1_0 1 Tf
10 0 0 10 84 109.99997 Tm
(http://journals.bmj.com/cgi/reprintform)Tj
0 g
/T1_1 1 Tf
T*
(To order reprints go to:)Tj
ET
BT
0 0 1 rg
/T1_0 1 Tf
10 0 0 10 84 75.99997 Tm
(http://group.bmj.com/subscribe/)Tj
0 g
/T1_1 1 Tf
T*
(To subscribe to BMJ go to:)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 404.21991 780 Tm
(group.bmj.com)Tj
0 g
-14.508 0 Td
( on July 21, 2016 - Published by )Tj
0 0 1 rg
-10.67097 0 Td
(http://bmjopen.bmj.com/)Tj
0 g
-8.11398 0 Td
(Downloaded from )Tj
ET
endstream
endobj
502 0 obj
<>/Filter/FlateDecode/Height 155/Length 8359/Name/X/Subtype/Image/Type/XObject/Width 246>>stream
HLTa0 EjDUۋPmmۤI[Ԥi#X)Mڤ)>&TEk""0cܟ9z30?r8^k[E"$"Ĵp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-"Ķp"Il'-".jpt]mXp8PZ탟wA\ATZWC)túD#ĝA NycZ=%$Gd]ujmo#FB3l"B4W,qR°0 &&D:,İ(%s1o~X8}zhttȤI&Nb6{K:~*m I%$|``px;6twoAt[g-*SF Qb%K]0~䑩0S`;6ݹsm7> oN!d8]'?ޚ!`A1 CbF8kS`Zϸ.XPRr{4bI /(Xf0A*/VTTUUeA\%sl11ݻO[-Zƿ^ܹ0v\[#|dV#,*3^K/ݿxq$ڰށW-lĎ
><|"
%KJ.SE?t~wߝղg'>H>Dc}}xcKVu$r8F=w==}KD];= PwzTu{T`_ Ƙ n|ϞӨ8II_@8=ex^}uSO=êG}s`|F6y#)'CIBIE*K G||d+`*0[&Vnh\Q/ECr
7;]V
G *\HdP|Dg18M!+ʕ+KKKą]!M֘4nOA)Zf[GG/ƌaa&Z6/.,<'$^JG8~ֺ:C'Ѐɓ"#
==NIrGL&sqq}τsKT0wLLfH=±wΜp馃3qsnc#aժխS
asbv+oxbs"Ippnҝ;O ;p6n\${4s9-3?
+[Ӱ04?),AP\ںl",fl6x'A/IN>
;Gq(5b߁"@g!<־r=lexYCKi6uĵAf̘Y'[ZlxX|>z]jdJ9s"H|ϋn۶81q'8cF8iBТ`"a"lpjP}9</ڼd*B%xǎe~~|?֮3/G