Sulfur(IV)-mediated carbon-carbon bond formationTools Dean, William Michael (2016) Sulfur(IV)-mediated carbon-carbon bond formation. PhD thesis, University of Nottingham.
AbstractThis thesis details the development of methods for and application of the synthesis of carbon carbon bonds using organic sulfur(IV) chemistry. More specifically, the formation of C(sp2) C(sp3) and C(sp3) C(sp3) bonds is explored in detail. The necessity for this research stems from a correlation between a high proportion of sp3 centres in drug candidates, and their success in clinical trials. By facilitating the synthesis of drug candidates with higher fractions of sp3 hybridised carbon atoms, it is hoped that the rate of candidates proceeding through clinical trials may increase.
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