Hutchinson, John P., Fogarty, Andrew W., McKeever, Tricia M. and Hubbard, Richard B.
(2016)
In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011.
American Journal of Respiratory and Critical Care Medicine, 193
(10).
pp. 1161-1167.
ISSN 1535-4970
Full text not available from this repository.
Abstract
Rationale: Surgical lung biopsy can help to determine a specific diagnosis in interstitial lung disease, but has associated risks. Most currently available mortality data are derived from case series and may not be generalizable to broader populations.
Objectives: We aimed to assess in-hospital mortality following surgical lung biopsy for interstitial lung disease in a national secondary care dataset from the United States.
Methods: Data were obtained from the 2000-2011 Nationwide Inpatient Sample. Cases were identified using International Classification of Diseases (ICD-9-CM) codes for interstitial lung disease and surgical lung biopsies. Lung resections and cases of lung cancer were excluded. Weighted data were used to estimate numbers of biopsies nationwide and in-hospital mortality, and multivariable logistic regression was used to adjust for sex, age, geographic region, co-morbidity, type of operation and provisional diagnosis.
Measurements and Main Results: We estimated there to be around 12,000 surgical lung biopsies performed annually for interstitial lung disease in the United States, two-thirds of which were performed electively. In-hospital mortality was 1.7% for elective procedures, but significantly higher for non-elective procedures (16.0%). Male sex, increasing age, increasing co-morbidity, open surgery and a provisional diagnosis of idiopathic pulmonary fibrosis or connective tissue disease related interstitial lung disease were risk factors for increased mortality.
Conclusions: In-hospital mortality following elective surgical lung biopsy for interstitial lung disease is just under 2%, but significantly higher for non-elective procedures. Identified risk factors for death should be taken into account when counselling patients on whether to pursue a histological diagnosis.
| Item Type: |
Article
|
| RIS ID: |
https://nottingham-repository.worktribe.com/output/789990 |
| Additional Information: |
Originally Published in:
John P Hutchinson, Andrew W Fogarty, Tricia M McKeever, and Richard B. Hubbard. In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011. American Journal of Respiratory and Critical Care Medicine 2015 ; Volume 193, issue 10, pages 1161-1167
DOI: 10.1164/rccm.201508-1632OC
Copyright © 2016 by the American Thoracic Society
The final publication is available at http://www.atsjournals.org/doi/10.1164/rccm.201508-1632OC |
| Keywords: |
Interstitial lung disease, Mortality, Surgery |
| Schools/Departments: |
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Epidemiology and Public Health |
| Identification Number: |
https://doi.org/10.1164/rccm.201508-1632OC |
| Depositing User: |
Hutchinson, John
|
| Date Deposited: |
19 Apr 2016 12:19 |
| Last Modified: |
04 May 2020 17:51 |
| URI: |
https://eprints.nottingham.ac.uk/id/eprint/32623 |
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