Blood type gene locus has no influence on ACE association with Alzheimer's disease

Braae, Anne, Medway, Christopher, Carrasquillo, Minerva, Younkin, Steven, Kehoe, Patrick G. and Morgan, Kevin (2015) Blood type gene locus has no influence on ACE association with Alzheimer's disease. Neurobiology of Aging, 36 (4). 1767.e1-1767.e2. ISSN 1558-1497

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The ABO blood group locus was recently found to contribute independently as well as via interactions with ACE gene variation to plasma levels of angiotensin converting enzyme (ACE). Variation in ACE has also previously been implicated as conferring susceptibility for Alzheimer’s disease (AD), but has also been proposed to confer risk via interactions with other as yet unknown genes. More recently, larger studies have not supported ACE as a risk factor for AD, while the role of ACE pathway in AD has come under increased levels of scrutiny with respect to various aspects of AD pathology and possible therapies. We explored the potential combined involvement of ABO and ACE variation in the genetic susceptibility of 2067 AD cases compared to 1376 non-demented elderly. Including the effects of ABO haplotype did not provide any evidence for the genetic association of ACE with AD.

Item Type: Article
Keywords: Alzheimer's disease, Angiotensin-converting enzyme, ABO blood group, Genome-wide association study
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences > School of Molecular Medical Sciences > Human Genetics Research Group
Identification Number:
Depositing User: Morgan, Kevin
Date Deposited: 10 Mar 2016 11:42
Last Modified: 04 May 2020 20:09

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