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Jayaprakasan, K., Pandian, D., Hopkisson, J., Campbell, B.K. and Maalouf, W.E. (2014) Effect of ethnicity on live birth rates after in vitro fertilisation or intracytoplasmic sperm injection treatment. BJOG: An International Journal of Obstetrics and Gynaecology, 121 (3). pp. 300-307. ISSN 1470-0328

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Abstract

Objective

To assess the relationship between the ethnicity of women and the clinical success of in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) treatment.

Design

Observational cohort study.

Setting

Nottingham University Research and Treatment Unit in Reproduction (NURTURE), UK.

Sample

A total of 1517 women, of which 1291 were white Europeans and 226 belonged to an ethnic minority group. All the women were undergoing their first cycle of assisted reproductive technology (ART) between 2006 and 2011.

Methods

All of the women underwent their first cycle of ART between 2006 and 2011.

Main outcome measures

Live birth rates following IVF or ICSI treatment.

Results

Although pre-treatment ovarian reserve variables [mean age, basal follicle stimulating hormone (FSH), and total antral follicle count] were significantly favourable in the ethnic group, the live birth rates were significantly lower in this group (35%) compared with the white European group (43.8%) (relative risk 0.8; 95% CI 0.66–0.97). On logistic regression analysis, ethnicity was an independent predictor of live birth rate (OR 0.688; 95% CI 0.513–0.924). After controlling for the other independent variables (age and FSH), the significant association between ethnicity and live birth rate remained strong (OR 0.591; 95% CI 0.425–0.822) on multivariate logistic regression analysis.

Conclusions

Live birth rates following IVF or ICSI treatment were significantly lower in the ethnic minority group compared with white European women, which suggests that ethnicity is a major determinant of live birth following IVF treatment.

Item Type:	Article
RIS ID:	https://nottingham-repository.worktribe.com/output/997034
Schools/Departments:	University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Child Health, Obstetrics and Gynaecology
Identification Number:	10.1111/1471-0528.12504
Depositing User:	de Sousa, Mrs Shona
Date Deposited:	11 Apr 2014 10:06
Last Modified:	04 May 2020 20:15
URI:	https://eprints.nottingham.ac.uk/id/eprint/2946

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