Chondrocalcinosis is common in the absence of knee involvement

Abhishek, Abishek, Doherty, Sally, Maciewicz, Rose, Muir, Kenneth, Zhang, Weiya and Doherty, Michael (2012) Chondrocalcinosis is common in the absence of knee involvement. Arthritis Research & Therapy, 14 (5). 5/1-5/5. ISSN 1478-6354

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Introduction: We aimed to describe the distribution of radiographic chondrocalcinosis (CC) and to examine

whether metacarpophalangeal joint (MCPJ) calcification and CC at other joints occurs in the absence of knee


Methods: This was a cross-sectional study embedded in the Genetics of Osteoarthritis and Lifestyle study (GOAL).

All participants (n = 3,170) had radiographs of the knees, hands, and pelvis. These were scored for radiographic

changes of osteoarthritis (OA), for CC at knees, hips, symphysis pubis, and wrists, and for MCPJ calcification. The

prevalence of MCPJ calcification and CC overall, at each joint, and in the presence or absence of knee involvement,

was calculated.

Results: The knee was the commonest site of CC, followed by wrists, hips, and symphysis pubis. CC was more

likely to be bilateral at knees and wrists but unilateral at hips. MCPJ calcification was usually bilateral, and less

common than CC at knees, hips, wrists, and symphysis pubis. Unlike that previously reported, CC commonly

occurred without any knee involvement; 44.4% of wrist CC, 45.9% of hip CC, 45.5% of symphysis pubis CC, and

31.3% of MCPJ calcification occurred in patients without knee CC. Those with meniscal or hyaline articular cartilage

CC had comparable ages (P = 0.21), and neither preferentially associated with fibrocartilage CC at distant joints.

Conclusions: CC visualized on a plain radiograph commonly occurs at other joints in the absence of radiographic

knee CC. Therefore, knee radiographs alone are an insufficient screening test for CC. This has significant

implications for clinical practice, for epidemiologic and genetic studies of CC, and for the definition of OA patients

with coexistent crystal deposition.

Item Type: Article
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine
Identification Number:
Depositing User: Johnson, Mrs Alison
Date Deposited: 11 Apr 2014 10:55
Last Modified: 04 May 2020 16:34

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