Dynamics of DNA replication in yeast

Retkute, Renata, Nieduszynski, Conrad A. and Moura, Alessandro de (2011) Dynamics of DNA replication in yeast. Physical Review Letters, 107 . 068103/1-068103/4. ISSN 0031-9007

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We present a mathematical model for the spatial dynamics of DNA replication. Using this model we determine the probability distribution for the time at which each chromosomal position is replicated. From this we show, contrary to previous reports, that mean replication time curves cannot be used to directly determine origin parameters. We demonstrate that the stochastic nature of replication dynamics leaves a clear signature in experimentally measured population average data, and we show that the width of the activation time probability distribution can be inferred from this data. Our results compare favorably with experimental measurements in Saccharomyces cerevisae.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/1009799
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences > School of Biology
Identification Number: https://doi.org/10.1103/PhysRevLett.107.068103
Depositing User: Liu, Mr Zhenxing
Date Deposited: 01 Apr 2014 08:04
Last Modified: 04 May 2020 20:23
URI: https://eprints.nottingham.ac.uk/id/eprint/2492

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