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Roadknight, Chris and Aickelin, Uwe and Qiu, Guoping and Scholefield, John and Durrant, Lindy (2012) Supervised learning and anti-learning of colorectal cancer classes and survival rates from cellular biology parameters. In: 2012 IEEE International Conference on Systems, Man and Cybernetics - SMC, 14-17 Oct 2012, Seoul, South Korea.

Abstract

In this paper, we describe a dataset relating to cellular

and physical conditions of patients who are operated upon to

remove colorectal tumours. This data provides a unique insight into immunological status at the point of tumour removal,tumour classification and post-operative survival. Attempts are made to learn relationships between attributes (physical andimmunological) and the resulting tumour stage and survival. Results for conventional machine learning approaches can be considered poor, especially for predicting tumour stages for the most important types of cancer. This poor performance is further investigated and compared with a synthetic, dataset based on the

logical exclusive-OR function and it is shown that there is a significant level of “anti-learning” present in all supervised methods used and this can be explained by the highly dimensional, complex and sparsely representative dataset. For predicting the stage of cancer from the immunological attributes,anti-learning approaches outperform a range of popular algorithms

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