Depolarization induced suppression of excitation and the emergence of ultra-slow rhythms in neural networksTools Hlinka, Jaroslav and Coombes, Stephen (2010) Depolarization induced suppression of excitation and the emergence of ultra-slow rhythms in neural networks. Physical Review Letters . ISSN 0031-9007 (In Press) Full text not available from this repository.
Official URL: http://prl.aps.org/
AbstractUltra-slow fluctuations (0.01-0.1 Hz) are a feature of intrinsic brain activity of as yet unclear origin. We propose a candidate mechanism based on retrograde endocannabinoid signaling in a synaptically coupled network of excitatory neurons. This is known to cause depolarization-induced suppression of excitation (DISE), which we model phenomenologically. We construct emergent network oscillations in a globally coupled network and show that for strong synaptic coupling DISE can lead to a synchronized population burst at the frequencies of resting brain rhythms.
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