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Number of items: 8.

Article

van der Westhuizen, Emma T. and Spathis, Arthur and Khajehali, Elham and Jörg, Manuela and Mistry, Shailesh N. and Capuano, Ben and Tobin, Andrew B. and Sexton, Patrick M. and Scammells, Peter J. and Valant, Celine and Christopoulos, Arthur (2018) Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors. Molecular Pharmacology . ISSN 1521-0111

Choy, Kwok H.C. and Shackleford, David M. and Malone, Daniel T. and Mistry, Shailesh N. and Patil, Rahul T. and Scammells, Peter J. and Langmead, Christopher J. and Pantelis, Christos and Sexton, Patrick M. and Lane, Jonathan R. and Christopoulos, Arthur (2016) Positive allosteric modulation of the muscarinic M1 receptor improves efficacy of antipsychotics in mouse glutamatergic deficit models of behavior. Journal of Pharmacology and Experimental Therapeutics, 359 (2). pp. 354-365. ISSN 1521-0103

Klein Herenbrink, Carmen and Sykes, David A. and Donthamsetti, Prashant and Canals, Meritxell and Coudrat, Thomas and Shonberg, Jeremy and Scammells, Peter J. and Capuano, Ben and Sexton, Patrick M. and Charlton, Steven J. and Javitch, Jonathan and Christopoulos, Arthur and Lane, J. Robert (2016) The role of kinetic context in apparent biased agonism at GPCRs. Nature Communications, 7 . 10842/1-10842/14. ISSN 2041-1723

Mistry, Shailesh N. and Jörg, Manuela and Lim, Herman and Vinh, Natalie B. and Sexton, Patrick M. and Capuano, Ben and Christopoulos, Arthur and Lane, J. Robert and Scammells, Peter J. (2015) 4-Phenylpyridin-2-one derivatives: a novel class of positive allosteric modulator of the M1 muscarinic acetylcholine receptor. Journal of Medicinal Chemistry . ISSN 1520-4804

Cook, A.E. and Mistry, Shailesh N. and Gregory, K.J. and Furness, S.G.B. and Sexton, Patrick M. and Scammells, Peter J. and Conigrave, A.D. and Christopoulos, Arthur and Leach, K. (2014) Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. British Journal of Pharmacology, 172 (1). pp. 185-200. ISSN 1476-5381

Abdul-Ridha, Alaa and Lane, J. Robert and Mistry, Shailesh N. and Lopez, Laura and Sexton, Patrick M. and Scammells, Peter J. and Christopoulos, Arthur and Canals, Meritxell (2014) Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor. Journal of Biological Chemistry, 289 (48). pp. 33701-33711. ISSN 0021-9258

Abdul-Ridha, Alaa and López, Laura and Keov, Peter and Thal, David M. and Mistry, Shailesh N. and Sexton, Patrick M. and Lane, J. Robert and Canals, Meritxell and Christopoulos, Arthur (2014) Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor. Journal of Biological Chemistry, 289 (9). pp. 6067-6079. ISSN 0021-9258

Mistry, Shailesh N. and Valant, Celine and Sexton, Patrick M. and Capuano, Ben and Christopoulos, Arthur and Scammells, Peter J. (2013) Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor. Journal of Medicinal Chemistry, 56 (12). pp. 5151-5172. ISSN 0022-2623

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