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Number of items: 23.

van der Westhuizen, Emma T. and Spathis, Arthur and Khajehali, Elham and Jörg, Manuela and Mistry, Shailesh N. and Capuano, Ben and Tobin, Andrew B. and Sexton, Patrick M. and Scammells, Peter J. and Valant, Celine and Christopoulos, Arthur (2018) Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors. Molecular Pharmacology . ISSN 1521-0111

Fyfe, Tim J. and Zarzycka, Barbara and Lim, Herman D. and Kellam, Barrie and Mistry, Shailesh N. and Katrich, Vsevolod and Scammells, Peter J. and Lane, J. Robert and Capuano, Ben (2018) A thieno[2,3-d]pyrimidine scaffold is a novel negative allosteric modulator of the dopamine D2 receptor. Journal of Medicinal Chemistry . ISSN 1520-4804

Baker, Jillian G. and Gardiner, Sheila M. and Woolard, Jeanette and Fromont, Christophe and Jadhav, Gopal P. and Mistry, Shailesh N. and Thompson, Kevin S.J. and Kellam, Barrie and Hill, Stephen J. and Fischer, Peter M. (2017) Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease. FASEB Journal, 31 (7). pp. 3150-3166. ISSN 1530-6860

Choy, Kwok H.C. and Shackleford, David M. and Malone, Daniel T. and Mistry, Shailesh N. and Patil, Rahul T. and Scammells, Peter J. and Langmead, Christopher J. and Pantelis, Christos and Sexton, Patrick M. and Lane, Jonathan R. and Christopoulos, Arthur (2016) Positive allosteric modulation of the muscarinic M1 receptor improves efficacy of antipsychotics in mouse glutamatergic deficit models of behavior. Journal of Pharmacology and Experimental Therapeutics, 359 (2). pp. 354-365. ISSN 1521-0103

Emtage, Abigail L. and Mistry, Shailesh N. and Fischer, Peter M. and Kellam, Barrie and Laughton, Charles A. (2016) GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors. Journal of Biomolecular Structure and Dynamics . pp. 1-16. ISSN 1538-0254

Mistry, Shailesh N. and Baker, Jillian G. (2016) The composite influence of the imidazolone moiety of CGP 12177 on its affinity and efficacy at the two conformations of the human β1-adrenoceptor. In: British Pharmacological Society - 6th Focused Meeting on Cell Signalling, Spring 2016, 18-19 Apr 2016, Leicester, UK.

Mistry, Shailesh N. and Baker, Jillian G. (2016) The effect of the N-alkyl moiety on the interaction of pindolol analogues with the two agonist conformations of the human β1-adrenoceptor. In: British Pharmacological Society 6th Focused Meeting on Cell Signalling 2016, 18-19 Apr 2016, Leicester, UK.

Mistry, Shailesh N. and Lim, Herman and Jörg, Manuela and Capuano, Ben and Christopoulos, Arthur and Lane, J. Robert and Scammells, Peter J. (2016) Novel fused arylpyrimidinone based allosteric modulators of the M1 muscarinic acetylcholine receptor. ACS Chemical Neuroscience, 7 (5). pp. 647-661. ISSN 1948-7193

Drinkwater, Nyssa and Vinh, Natalie B. and Mistry, Shailesh N. and Bamert, Rebecca S. and Ruggeri, Chiara and Holleran, John P. and Loganathan, Sasdekumar and Paiardini, Alessandro and Charman, Susan A. and Powell, Andrew K. and Avery, Vicky M. and McGowan, Sheena and Scammells, Peter J. (2016) Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. European Journal of Medicinal Chemistry . ISSN 0223-5234 (In Press)

Mistry, Shailesh N. and Jörg, Manuela and Lim, Herman and Vinh, Natalie B. and Sexton, Patrick M. and Capuano, Ben and Christopoulos, Arthur and Lane, J. Robert and Scammells, Peter J. (2015) 4-Phenylpyridin-2-one derivatives: a novel class of positive allosteric modulator of the M1 muscarinic acetylcholine receptor. Journal of Medicinal Chemistry . ISSN 1520-4804

Mistry, Shailesh N. and Shonberg, Jeremy and Draper-Joyce, Christopher J. and Klein Herenbrink, Carmen and Michino, Mayako and Shi, Lei and Christopoulos, Arthur and Capuano, Ben and Scammells, Peter J. and Lane, J. Robert (2015) Discovery of a novel class of negative allosteric modulator of the dopamine D2 receptor through fragmentation of a bitopic ligand. Journal of Medicinal Chemistry, 58 (17). pp. 6819-6843. ISSN 0022-2623

Shonberg, Jeremy and Draper-Joyce, Christopher and Mistry, Shailesh N. and Christopoulos, Arthur and Scammells, Peter J. and Lane, J. Robert and Capuano, Ben (2015) Structure–activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor. Journal of Medicinal Chemistry, 58 (13). pp. 5287-5307. ISSN 0022-2623

Paiardini, Alessandro and Bamert, Rebecca S. and Kannan-Sivaraman, Komagal and Drinkwater, Nyssa and Mistry, Shailesh N. and Scammells, Peter J. and McGowan, Sheena (2015) Screening the medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18. PLoS ONE, 10 (2). e0115859/1-e0115859/14. ISSN 1932-6203

Cook, A.E. and Mistry, Shailesh N. and Gregory, K.J. and Furness, S.G.B. and Sexton, Patrick M. and Scammells, Peter J. and Conigrave, A.D. and Christopoulos, Arthur and Leach, K. (2014) Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. British Journal of Pharmacology, 172 (1). pp. 185-200. ISSN 1476-5381

Abdul-Ridha, Alaa and Lane, J. Robert and Mistry, Shailesh N. and Lopez, Laura and Sexton, Patrick M. and Scammells, Peter J. and Christopoulos, Arthur and Canals, Meritxell (2014) Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor. Journal of Biological Chemistry, 289 (48). pp. 33701-33711. ISSN 0021-9258

Mistry, Shailesh N. and Drinkwater, Nyssa and Ruggeri, Chiara and Sivaraman, Komagal Kannan and Loganathan, Sasdekumar and Fletcher, Sabine and Drag, Marcin and Paiardini, Alessandro and Avery, Vicky M. and Scammells, Peter J. and McGowan, Sheena (2014) Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors. Journal of Medicinal Chemistry, 57 (21). pp. 9168-9183. ISSN 0022-2623

Abdul-Ridha, Alaa and López, Laura and Keov, Peter and Thal, David M. and Mistry, Shailesh N. and Sexton, Patrick M. and Lane, J. Robert and Canals, Meritxell and Christopoulos, Arthur (2014) Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor. Journal of Biological Chemistry, 289 (9). pp. 6067-6079. ISSN 0021-9258

Mistry, Shailesh N. and Valant, Celine and Sexton, Patrick M. and Capuano, Ben and Christopoulos, Arthur and Scammells, Peter J. (2013) Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor. Journal of Medicinal Chemistry, 56 (12). pp. 5151-5172. ISSN 0022-2623

Mistry, Shailesh N. and Baker, Jillian G. and Fischer, Peter M. and Hill, Stephen J. and Gardiner, Sheila M. and Kellam, Barrie (2013) Synthesis and in vitro and in vivo characterization of highly β1-Selective β-Adrenoceptor partial agonists. Journal of Medicinal Chemistry, 56 (10). pp. 3852-3865. ISSN 0022-2623

Baker, Jillian G. and Mistry, Shailesh N. and Fischer, Peter M. and Hill, Stephen J. and Gardiner, Sheila M. and Kellam, Barrie (2012) In vitro and in vivo analysis of a novel highly selective β1-adrenoceptor partial agonist. In: British Pharmacological Society 4th Focused Meeting on Cell Signalling, 23-24 April 2012, Leicester, UK.

Baker, Jillian G. and Adams, Luke A. and Salchow, Karolina and Mistry, Shailesh N. and Middleton, Richard J. and Hill, Stephen J. and Kellam, Barrie (2011) Synthesis and characterization of high-affinity 4, 4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors. Journal of Medicinal Chemistry, 54 (19). pp. 6874-6887. ISSN 0022-2623

Baker, Jillian G. and Adams, Luke A. and Salchow, Karolina and Mistry, Shailesh N. and Middleton, Richard J. and Hill, Stephen J. and Kellam, Barrie (2011) Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors. Journal of Medicinal Chemistry, 54 (19). pp. 6874-6887. ISSN 0022-2623

Mistry, Shailesh N. (2009) Structure activity relationships of novel and selective beta1-adrenoreceptor ligands. PhD thesis, University of Nottingham.

This list was generated on Fri Sep 21 16:40:43 2018 UTC.