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Number of items: 28.

Article

Kilpatrick, Laura E. and Friedman-Ohana, Rachel and Alcobia, Diana C. and Riching, Kristin and Peach, Chloe J. and Wheal, Amanda J. and Briddon, Stephen J. and Robers, Matthew B. and Zimmerman, Kris and Machleidt, Thomas and Wood, Keith V. and Woolard, Jeanette and Hill, Stephen J. (2017) Real-time analysis of the binding of fluorescent VEGF₁₆₅a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes. Biochemical Pharmacology . ISSN 1873-2968 (In Press)

Baker, Jillian G. and Gardiner, Sheila M. and Woolard, Jeanette and Fromont, Christophe and Jadhav, Gopal P. and Mistry, Shailesh N. and Thompson, Kevin S.J. and Kellam, Barrie and Hill, Stephen J. and Fischer, Peter M. (2017) Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease. FASEB Journal . ISSN 1530-6860 (In Press)

Schwehm, Carolin and Kellam, Barrie and Garces, Aimie and Hill, Stephen J. and Kindon, Nicholas and Bradshaw, Tracey D. and Li, Jin and Macdonald, Simon J.F. and Rowedder, James E. and Stoddart, Leigh A. and Stocks, Michael (2017) Design and elaboration of a tractable tricyclic scaffold to synthesize druglike inhibitors of dipeptidyl peptidase-4 (DPP-4), antagonists of the C–C Chemokine Receptor Type 5 (CCR5), and highly potent and selective phosphoinositol-3 Kinase δ (PI3Kδ) inhibitors. Journal of Medicinal Chemistry, 60 (4). pp. 1534-1554. ISSN 1520-4804

Hothersall, J. Daniel and Guo, Dong and Sarda, Sunil and Sheppard, Robert J. and Chen, Hongming and Keur, Wesley and Waring, Michael J. and IJzerman, Adriaan P. and Hill, Stephen J. and Dale, Ian L. and Rawlins, Philip B. (2017) Structure-activity relationships of the sustained effects of adenosine A2A receptor agonists driven by slow dissociation kinetics. Molecular Pharmacology, 91 (1). pp. 25-38. ISSN 1521-0111

Soave, Mark and Stoddart, Leigh A. and Brown, Alastair and Woolard, Jeanette and Hill, Stephen J. (2016) Use of a new proximity assay (NanoBRET) to investigate the ligand binding characteristics of three fluorescent ligands to the human β1-adrenoceptor expressed in HEK-293 cells. Pharmacology Research and Perspectives, 4 (5). e00250/1-e00250/13. ISSN 2052-1707

Kilpatrick, Laura E. and Hill, Stephen J. (2016) The use of fluorescence correlation spectroscopy to characterize the molecular mobility of fluorescently labelled G protein-coupled receptors. Biochemical Society Transactions, 44 (2). pp. 624-629. ISSN 0300-5127

Ranganathan, Anirudh and Stoddart, Leigh A. and Hill, Stephen J. and Carlsson, Jens (2015) Fragment-based discovery of subtype-selective adenosine receptor ligands from homology models. Journal of Medicinal Chemistry, 58 (24). pp. 9578-9590. ISSN 1520-4804

Blaxter, L.L. and Morris, David E. and Crowe, John A. and Henry, C. and Hill, Stephen J. and Sharkey, Don and Vyas, H. and Hayes-Gill, Barrie R. (2015) An automated quasi-continuous capillary refill timing device. Physiological Measurement, 37 (1). ISSN 1361-6579

Stoddart, Leigh A. and Vernall, Andrea J. and Briddon, Stephen J. and Kellam, Barrie and Hill, Stephen J. (2015) Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist. Neuropharmacology, 98 . pp. 68-77. ISSN 1873-7064

Gherbi, Karolina and May, Lauren T. and Baker, Jillian G. and Briddon, Stephen J. and Hill, Stephen J. (2015) Negative cooperativity across 1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 1-adrenoceptor binding conformation. FASEB Journal, 29 (7). pp. 2859-2871. ISSN 1530-6860

Stoddart, Leigh A. and Johnstone, Elizabeth K.M. and Wheal, Amanda J. and Goulding, Joelle and Robers, Matthew B. and Machleidt, Thomas and Wood, Keith V. and Hill, Stephen J. and Pfleger, Kevin D.G. (2015) Application of BRET to monitor ligand binding to GPCRs. Nature Methods, 12 . pp. 661-663. ISSN 1548-7105

Carter, Joanne J. and Wheal, Amanda J. and Hill, Stephen J. and Woolard, Jeanette (2015) Effects of receptor tyrosine kinase inhibitors on VEGF165a- and VEGF165b-stimulated gene transcription in HEK-293 cells expressing human VEGFR2. British Journal of Pharmacology, 172 (12). pp. 3141-3150. ISSN 1476-5381

Baker, Jillian G. and Proudman, Richard G.W. and Hill, Stephen J. (2015) Salmeterol's extreme b2 selectivity is due to residues in both extracellular loops and transmembrane domains. Molecular Pharmacology, 87 (1). pp. 103-120. ISSN 1521-0111

Corriden, Ross and Kilpatrick, Laura E. and Kellam, Barrie and Briddon, Stephen J. and Hill, Stephen J. (2014) Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism. FASEB Journal, 28 (10). pp. 4211-4222. ISSN 1530-6860

Stoddart, Leigh A. and Kellam, Barrie and Briddon, Stephen J. and Hill, Stephen J. (2014) Effect of a toggle switch mutation in TM6 of the human adenosine A3 receptor on Gi protein-dependent signalling and Gi-independent receptor internalization. British Journal of Pharmacology, 171 (16). pp. 3827-3844. ISSN 0007-1188

Baker, Jillian G. and Proudman, Richard G.W. and Hill, Stephen J. (2014) Identification of key residues in transmembrane 4 responsible for the secondary, low-affinity conformation of the human 1-adrenoceptor. Molecular Pharmacology, 85 (5). pp. 811-829. ISSN 1521-0111

Hill, Stephen J. and May, Lauren T. and Kellam, Barrie and Woolard, Jeanette (2014) Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization. British Journal of Pharmacology, 171 (5). pp. 1102-1113. ISSN 0007-1188

Vernall, Andrea J. and Hill, Stephen J. and Kellam, Barrie (2014) The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs. British Journal of Pharmacology, 171 (5). pp. 1073-1084. ISSN 0007-1188

Hutchings, Catherine J. and Cseke, Gabriella and Osborne, Greg and Woolard, Jeanette and Zhukov, Andrei and Koglin, Markus and Jazayeri, Ali and Pandya-Pathak, Jahnavi and Langmead, Christopher J. and Hill, Stephen J. and Weir, Malcolm and Marshall, Fiona H. (2013) Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment. mAbs, 6 (1). pp. 246-261. ISSN 1942-0870

Baker, Jillian G. and Hill, Stephen J. and Proudman, Richard G.W. (2013) Impact of polymorphic variants on the molecular pharmacology of the two-agonist conformations of the human β1-adrenoceptor. PLoS ONE, 8 (11). ISSN 1932-6203

Vernall, Andrea J. and Stoddart, Leigh A. and Briddon, Stephen J. and Ng, Hui Wen and Laughton, Charles A. and Doughty, Stephen W. and Hill, Stephen J. and Kellam, Barrie (2013) Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers. Organic & Biomolecular Chemistry, 11 (34). pp. 5673-5682. ISSN 1477-0520

Corriden, Ross and Self, Tim and Akong-Moore, Kathryn and Nizet, Victor and Kellam, Barrie and Briddon, Stephen J. and Hill, Stephen J. (2013) Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. EMBO reports, 14 (8). pp. 726-732. ISSN 1469-221X

Mistry, Shailesh Natvarbhai and Baker, Jillian G. and Fischer, Peter M. and Hill, Stephen J. and Gardiner, Sheila M. and Kellam, Barrie (2013) Synthesis and in vitro and in vivo characterization of highly β1-Selective β-Adrenoceptor partial agonists. Journal of Medicinal Chemistry, 56 (10). pp. 3852-3865. ISSN 0022-2623

Baker, Jillian G. and Kemp, Philip and March, Julie and Fretwell, Laurice and Hill, Stephen J. and Gardiner, Sheila M. (2011) Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantative comparison of cellular and cardiovascular pharmacological responses. FASEB Journal, 25 (12). pp. 4486-4497. ISSN 0892-6638

Baker, Jillian G. and Adams, Luke A. and Salchow, Karolina and Mistry, Shailesh Natvarbhai and Middleton, Richard J. and Hill, Stephen J. and Kellam, Barrie (2011) Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors. Journal of Medicinal Chemistry, 54 (19). pp. 6874-6887. ISSN 0022-2623

Baker, Jillian G. and Adams, Luke A. and Salchow, Karolina and Mistry, Shailesh N. and Middleton, Richard J. and Hill, Stephen J. and Kellam, Barrie (2011) Synthesis and characterization of high-affinity 4, 4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors. Journal of Medicinal Chemistry, 54 (19). pp. 6874-6887. ISSN 0022-2623

Baker, Jillian G. and Hill, Stephen J. and Summers, Roger J. (2011) Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling. Trends in Pharmacological Sciences, 32 (4). pp. 227-234. ISSN 0165-6147

Conference or Workshop Item

Baker, Jillian G. and Mistry, Shailesh N. and Fischer, Peter M. and Hill, Stephen J. and Gardiner, Sheila M. and Kellam, Barrie (2012) In vitro and in vivo analysis of a novel highly selective β1-adrenoceptor partial agonist. In: British Pharmacological Society 4th Focused Meeting on Cell Signalling, 23-24 April 2012, Leicester, UK.

This list was generated on Tue Oct 17 04:16:40 2017 UTC.