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Jump to: Article Number of items: 8. ArticleRoberts, Maxine J. and Broome, Rebecca E. and Kent, Toby C. and Charlton, Steven J. and Rosethorne, Elizabeth M. (2018) The inhibition of human lung fibroblast proliferation and differentiation by Gs-coupled receptors is not predicted by the magnitude of cAMP response. Respiratory Research, 19 . 56/1-56/13. ISSN 1465-993X Michel, Martin C. and Charlton, Steven J. (2018) Biased agonism in drug discovery: is it too soon to choose a path? Molecular Pharmacology, 93 (4). pp. 259-265. ISSN 0026-895X Gherbi, Karolina and Briddon, Stephen J. and Charlton, Steven J. (2018) Micro-pharmacokinetics: quantifying local drug concentration at live cell membranes. Scientific Reports, 8 . 3479/1-3479/8. ISSN 2045-2322 Sykes, David A. and Moore, Holly and Stott, Lisa and Holliday, Nicholas and Javitch, Jonathan A. and Lane, J. Robert and Charlton, Steven J. (2017) Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors. Nature Communications, 8 (1). 763/1-763/11. ISSN 2041-1723 Sandham, David A. and Barker, Lucy and Brown, Lyndon and Brown, Zarin and Budd, David and Charlton, Steven J. and Chatterjee, Devnanden and Cox, Brian and Dubois, Gerald and Duggan, Nicholas and Hall, Edward and Hatto, Julia and Maas, Janet and Manini, Jodie and Profit, Rachael and Riddy, Darren and Ritchie, Catherine and Sohal, Bindi and Shaw, Duncan and Stringer, Rowan and Sykes, David A. and Thomas, Matthew and Turner, Katherine L. and Watson, Simon J. and West, Ryan and Willard, Elisabeth and Williams, Gareth and Willis, Jennifer (2017) Discovery of fevipiprant (NVP-QAW039), a potent and selective DP2 receptor antagonist for treatment of asthma. ACS Medicinal Chemistry Letters, 8 . pp. 582-586. ISSN 1948-5875 Dickson, Callum J. and Hornak, Victor and Velez-Vega, Camilo and McKay, Daniel J.J. and Reilly, John and Sandham, David A. and Shaw, Duncan and Fairhurst, Robin A. and Charlton, Steven J. and Sykes, David A. and Pearlstein, Robert and Duca, Jose S. (2016) Uncoupling the structure–activity relationships of β2 adrenergic receptor ligands from membrane binding. Journal of Medicinal Chemistry, 59 (12). pp. 5780-5789. ISSN 1520-4804 Rosethorne, Elizabeth M. and Bradley, Michelle E. and Gherbi, Karolina and Sykes, David A. and Sattikar, Afrah and Wright, John D. and Renard, Emilie and Trifilieff, A. and Fairhurst, Robin A. and Charlton, Steven J. (2016) Long receptor residence time of C26 contributes to super agonist activity at the human β2 adrenoceptor. Molecular Pharmacology, 89 (4). pp. 467-475. ISSN 1521-0111 Klein Herenbrink, Carmen and Sykes, David A. and Donthamsetti, Prashant and Canals, Meritxell and Coudrat, Thomas and Shonberg, Jeremy and Scammells, Peter J. and Capuano, Ben and Sexton, Patrick M. and Charlton, Steven J. and Javitch, Jonathan and Christopoulos, Arthur and Lane, J. Robert (2016) The role of kinetic context in apparent biased agonism at GPCRs. Nature Communications, 7 . 10842/1-10842/14. ISSN 2041-1723 |
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