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Jump to: Article Number of items: 8. Articlevan der Westhuizen, Emma T. and Spathis, Arthur and Khajehali, Elham and Jörg, Manuela and Mistry, Shailesh N. and Capuano, Ben and Tobin, Andrew B. and Sexton, Patrick M. and Scammells, Peter J. and Valant, Celine and Christopoulos, Arthur (2018) Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors. Molecular Pharmacology . ISSN 1521-0111 Fyfe, Tim J. and Zarzycka, Barbara and Lim, Herman D. and Kellam, Barrie and Mistry, Shailesh N. and Katrich, Vsevolod and Scammells, Peter J. and Lane, J. Robert and Capuano, Ben (2018) A thieno[2,3-d]pyrimidine scaffold is a novel negative allosteric modulator of the dopamine D2 receptor. Journal of Medicinal Chemistry . ISSN 1520-4804 Klein Herenbrink, Carmen and Sykes, David A. and Donthamsetti, Prashant and Canals, Meritxell and Coudrat, Thomas and Shonberg, Jeremy and Scammells, Peter J. and Capuano, Ben and Sexton, Patrick M. and Charlton, Steven J. and Javitch, Jonathan and Christopoulos, Arthur and Lane, J. Robert (2016) The role of kinetic context in apparent biased agonism at GPCRs. Nature Communications, 7 . 10842/1-10842/14. ISSN 2041-1723 Mistry, Shailesh N. and Lim, Herman and Jörg, Manuela and Capuano, Ben and Christopoulos, Arthur and Lane, J. Robert and Scammells, Peter J. (2016) Novel fused arylpyrimidinone based allosteric modulators of the M1 muscarinic acetylcholine receptor. ACS Chemical Neuroscience, 7 (5). pp. 647-661. ISSN 1948-7193 Mistry, Shailesh N. and Jörg, Manuela and Lim, Herman and Vinh, Natalie B. and Sexton, Patrick M. and Capuano, Ben and Christopoulos, Arthur and Lane, J. Robert and Scammells, Peter J. (2015) 4-Phenylpyridin-2-one derivatives: a novel class of positive allosteric modulator of the M1 muscarinic acetylcholine receptor. Journal of Medicinal Chemistry . ISSN 1520-4804 Mistry, Shailesh N. and Shonberg, Jeremy and Draper-Joyce, Christopher J. and Klein Herenbrink, Carmen and Michino, Mayako and Shi, Lei and Christopoulos, Arthur and Capuano, Ben and Scammells, Peter J. and Lane, J. Robert (2015) Discovery of a novel class of negative allosteric modulator of the dopamine D2 receptor through fragmentation of a bitopic ligand. Journal of Medicinal Chemistry, 58 (17). pp. 6819-6843. ISSN 0022-2623 Shonberg, Jeremy and Draper-Joyce, Christopher and Mistry, Shailesh N. and Christopoulos, Arthur and Scammells, Peter J. and Lane, J. Robert and Capuano, Ben (2015) Structure–activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor. Journal of Medicinal Chemistry, 58 (13). pp. 5287-5307. ISSN 0022-2623 Mistry, Shailesh N. and Valant, Celine and Sexton, Patrick M. and Capuano, Ben and Christopoulos, Arthur and Scammells, Peter J. (2013) Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor. Journal of Medicinal Chemistry, 56 (12). pp. 5151-5172. ISSN 0022-2623 |
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