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Number of items: 15.

Article

Baker, Jillian G. and Gardiner, Sheila M. and Woolard, Jeanette and Fromont, Christophe and Jadhav, Gopal P. and Mistry, Shailesh N. and Thompson, Kevin S.J. and Kellam, Barrie and Hill, Stephen J. and Fischer, Peter M. (2017) Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease. FASEB Journal, 31 (7). pp. 3150-3166. ISSN 1530-6860

Schmidt, Denis and Gunera, Jakub and Baker, Jillian G. and Kolb, Peter (2017) Similarity- and substructure-based development of β2-adrenergic receptor ligands based on unusual scaffolds. ACS Medicinal Chemistry Letters . ISSN 1948-5875

Sato, Tomomi and Baker, Jillian G. and Warne, Tony and Brown, Giles A. and Leslie, Andrew and Congreve, Miles and Tate, Christopher G. (2015) Pharmacological analysis and structure determination of 7-methylcyanopindolol–bound b1-adrenergic receptor. Molecular Pharmacology, 88 (6). pp. 1024-1034. ISSN 1521-0111

Gherbi, Karolina and May, Lauren T. and Baker, Jillian G. and Briddon, Stephen J. and Hill, Stephen J. (2015) Negative cooperativity across 1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 1-adrenoceptor binding conformation. FASEB Journal, 29 (7). pp. 2859-2871. ISSN 1530-6860

Baker, Jillian G. and Proudman, Richard G.W. and Hill, Stephen J. (2015) Salmeterol's extreme b2 selectivity is due to residues in both extracellular loops and transmembrane domains. Molecular Pharmacology, 87 (1). pp. 103-120. ISSN 1521-0111

Baker, Jillian G. and Proudman, Richard G.W. and Hill, Stephen J. (2014) Identification of key residues in transmembrane 4 responsible for the secondary, low-affinity conformation of the human 1-adrenoceptor. Molecular Pharmacology, 85 (5). pp. 811-829. ISSN 1521-0111

Baker, Jillian G. and Hill, Stephen J. and Proudman, Richard G.W. (2013) Impact of polymorphic variants on the molecular pharmacology of the two-agonist conformations of the human β1-adrenoceptor. PLoS ONE, 8 (11). ISSN 1932-6203

Mistry, Shailesh Natvarbhai and Baker, Jillian G. and Fischer, Peter M. and Hill, Stephen J. and Gardiner, Sheila M. and Kellam, Barrie (2013) Synthesis and in vitro and in vivo characterization of highly β1-Selective β-Adrenoceptor partial agonists. Journal of Medicinal Chemistry, 56 (10). pp. 3852-3865. ISSN 0022-2623

Baker, Jillian G. and Kemp, Philip and March, Julie and Fretwell, Laurice and Hill, Stephen J. and Gardiner, Sheila M. (2011) Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantative comparison of cellular and cardiovascular pharmacological responses. FASEB Journal, 25 (12). pp. 4486-4497. ISSN 0892-6638

Baker, Jillian G. and Adams, Luke A. and Salchow, Karolina and Mistry, Shailesh Natvarbhai and Middleton, Richard J. and Hill, Stephen J. and Kellam, Barrie (2011) Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors. Journal of Medicinal Chemistry, 54 (19). pp. 6874-6887. ISSN 0022-2623

Baker, Jillian G. and Adams, Luke A. and Salchow, Karolina and Mistry, Shailesh N. and Middleton, Richard J. and Hill, Stephen J. and Kellam, Barrie (2011) Synthesis and characterization of high-affinity 4, 4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors. Journal of Medicinal Chemistry, 54 (19). pp. 6874-6887. ISSN 0022-2623

Baker, Jillian G. and Hill, Stephen J. and Summers, Roger J. (2011) Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling. Trends in Pharmacological Sciences, 32 (4). pp. 227-234. ISSN 0165-6147

Conference or Workshop Item

Mistry, Shailesh N. and Baker, Jillian G. (2016) The composite influence of the imidazolone moiety of CGP 12177 on its affinity and efficacy at the two conformations of the human β1-adrenoceptor. In: British Pharmacological Society - 6th Focused Meeting on Cell Signalling, Spring 2016, 18-19 Apr 2016, Leicester, UK.

Mistry, Shailesh N. and Baker, Jillian G. (2016) The effect of the N-alkyl moiety on the interaction of pindolol analogues with the two agonist conformations of the human β1-adrenoceptor. In: British Pharmacological Society 6th Focused Meeting on Cell Signalling 2016, 18-19 Apr 2016, Leicester, UK.

Baker, Jillian G. and Mistry, Shailesh N. and Fischer, Peter M. and Hill, Stephen J. and Gardiner, Sheila M. and Kellam, Barrie (2012) In vitro and in vivo analysis of a novel highly selective β1-adrenoceptor partial agonist. In: British Pharmacological Society 4th Focused Meeting on Cell Signalling, 23-24 April 2012, Leicester, UK.

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