Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care-5-year follow-up of a proof-of-concept study

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Abhishek, Abhishek, Jenkins, Wendy, La-Crette, Jonathan, Fernandes, Gwen Sascha and Doherty, Michael (2016) Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care-5-year follow-up of a proof-of-concept study. Rheumatology, 56 (4). pp. 529-533. ISSN 1462-0332

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Official URL: https://academic.oup.com/rheumatology/article/56/4/529/2671019

Abstract

Objectives: To evaluate the persistence and adherence on urate-lowering treatment (ULT) in primary care 5 years after an initial nurse-led treatment of gout.

Methods: One hundred gout patients initiated on up-titrated ULT between March and July 2010 were sent a questionnaire that elicited information on current ULT, reasons for discontinuation of ULT if applicable, medication adherence and generic and disease-specific quality-of-life measures in 2015. They were invited for one visit at which height and weight were measured and blood was collected for serum uric acid measurement.

Results: Seventy-five patients, mean age 68.13 years ( s . d . 10.07) and disease duration 19.44 years ( s . d . 13), returned completed questionnaires. The 5-year persistence on ULT was 90.7% (95% CI 81.4, 91.6) and 85.3% of responders self-reported taking ULT ⩾6 days/week. Of the 65 patients who attended the study visit, the mean serum uric acid was 292.8 μmol/l ( s . d . 97.2).

Conclusion: An initial treatment that includes individualized patient education and involvement in treatment decisions results in excellent adherence and persistence on ULT >4 years after the responsibility of treatment is taken over by the patient's general practitioner, suggesting that this model of gout management should be widely adopted.

Item Type:

Article

RIS ID:

https://nottingham-repository.worktribe.com/output/833843

Additional Information:

This is a pre-copyedited, author-produced version of an article accepted for publication in Rheumatology following peer review. The version of record Abhishek Abhishek, Wendy Jenkins, Jonathan La-Crette, Gwen Fernandes, Michael Doherty; Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care—5-year follow-up of a proof-of-concept study, Rheumatology, Volume 56, Issue 4, 1 April 2017, Pages 529–533 is available online at: https://academic.oup.com/rheumatology/article/56/4/529/2671019.

Keywords:

gout, urate lowering treatment, persistence, adherence

Schools/Departments:

University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Rheumatology, Orthopaedics and Dermatology

Identification Number:

https://doi.org/10.1093/rheumatology/kew395

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