Signature-tagged transposon mutagenesis identifies novel mycobacterium tuberculosis genes involved in the parasitism of human macrophages

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Rosas-Magallanes, Vania, Stadthagen-Gomez, Gustavo, Rauzier, Jean, Barreiro, Luis B., Tailleux, Ludovic, Boudou, Frédéric, Griffin, Ruth, Nigou, Jérome, Jackson, Mary, Gicquel, Brigittte and Neyrolles, Olivier (2007) Signature-tagged transposon mutagenesis identifies novel mycobacterium tuberculosis genes involved in the parasitism of human macrophages. Infection and Immunity, 75 (1). 504 -507. ISSN 1098-5522

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Abstract

Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells.

Item Type: Article
RIS ID: https://nottingham-repository.worktribe.com/output/703873
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences > School of Molecular Medical Sciences > Bacteriology
Identification Number: https://doi.org/10.1128/IAI.00058-06.
Depositing User: Griffin, Ruth
Date Deposited: 13 Dec 2017 14:25
Last Modified: 04 May 2020 16:26
URI: https://eprints.nottingham.ac.uk/id/eprint/48696

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