Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia

Smith-Jackson, Kate, Hentschke, Marta, Poli-de-Figueiredo, Carlos, Pinheiro da Costa, Bartira, Broughton Pipkin, Fiona, Czajka, Anna and Mistry, Hiten D. (2015) Placental expression of eNOS, iNOS and the major protein components of caveolae in women with pre-eclampsia. Placenta, 36 (5). pp. 607-610. ISSN 1532-3102

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Available under Licence Creative Commons Attribution Non-commercial No Derivatives.
Download (334kB) | Preview

Abstract

Caveolae regulate many cardiovascular functions and thus could be of interest in relation to pre-eclampsia, a pregnancy specific disorder characterised by hypertension and proteinuria. We examined placental mRNA and protein expression/localisation of the caveolae components Caveolin 1-3, Cavin 1-4 as well as eNOS/ iNOS in normotensive control (n=24) and pre-eclamptic pregnancies (n=19). Placental mRNA expression of caveolin-1, cavin 1-3, was lower and eNOS expression was increased in pre-eclampsia (P<0.05 for all). Additionally Caveolin-1 protein expression was also reduced in pre-eclampsia (P=0.007); this could be an adaptive response in pre-eclampsia, possibly to attenuate the oxidative stress/inflammation.

Item Type: Article
Keywords: Hypertension; Cavin; Caveolin; Pre-eclampsia; Placenta
Schools/Departments: University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Child Health, Obstetrics and Gynaecology
Identification Number: https://doi.org/10.1016/j.placenta.2015.02.001
Depositing User: Mistry, Hiten
Date Deposited: 21 Jul 2017 10:11
Last Modified: 12 Oct 2017 23:35
URI: https://eprints.nottingham.ac.uk/id/eprint/44328

Actions (Archive Staff Only)

Edit View Edit View