Mohamed, Ahmed Aboelfadle, Yosef, Ali Haroun, James, Cathryn, Al-Hussaini, Tarek Khalaf, Bedaiwy, Mohamed Ali and Amer, Saad A.
(2017)
Ovarian reserve after salpingectomy: a systematic review and meta-analysis.
Acta Obstetricia et Gynecologica Scandinavica, 96
(7).
pp. 795-803.
ISSN 1600-0412
Abstract
Introduction
Although there has been a growing concern over the possible damaging effect of salpingectomy on ovarian reserve, this issue remains uncertain. The purpose of this meta-analysis was to test the hypothesis that salpingectomy may compromise ovarian reserve.
Material and methods
A detailed search was conducted using MEDLINE, Embase, Dynamed Plus, ScienceDirect, TRIP database and the Cochrane Library from January 2000 to November 2016. All cohort, cross-sectional and randomized controlled studies investigating changes in circulating anti-Müllerian hormone (AMH) after salpingectomy were considered. Thirty-seven studies were identified, of which eight were eligible. Data were extracted and entered into RevMan software for calculation of the weighted mean difference (WMD) and 95% CI. Two groups of studies were analyzed separately: group 1 (six studies, n = 464) comparing data before and after salpingectomy and group 2 (two studies) comparing data in women who have undergone salpingectomy (n = 169) vs. healthy controls (n = 154).
Results
Pooled results of group 1 studies showed no statistically significant change in serum AMH concentration after salpingectomy (WMD, −0.10 ng/mL; 95% CI −0.19 to 0.00, I2 = 0%). Similarly, meta-analysis of group 2 showed no statistically significant difference in serum AMH concentration between salpingectomy group and controls (WMD, −0.11 ng/mL; 95% CI −0.37 to 0.14, I2 = 77%). Subgroup analyses based on laterality of surgery, type of AMH kit and participants’ age (<40 years) still showed no statistically significant changes in circulating AMH.
Conclusion
Salpingectomy does not seem to compromise ovarian reserve in the short-term. However, the long-term effect of salpingectomy on ovarian reserve remains uncertain.
| Item Type: |
Article
|
| Additional Information: |
This is the peer reviewed version of the following article: Mohamed AA, Yosef AH, James C, Al-Hussaini TK, Bedaiwy MA, Amer SAKS. Ovarian reserve after salpingectomy: a systematic review and meta-analysis. Acta Obstet Gynecol Scand 2017; 96:795–803., which has been published in final form at https://doi.org/10.1111/aogs.13133. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| Keywords: |
Salpingectomy, Ovarian reserve, Anti-Müllerian hormone, Ovarian function, Laparoscopy |
| Schools/Departments: |
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Medicine > Division of Medical Sciences and Graduate Entry Medicine |
| Identification Number: |
https://doi.org/10.1111/aogs.13133 |
| Depositing User: |
Eprints, Support
|
| Date Deposited: |
17 Jul 2017 14:36 |
| Last Modified: |
08 May 2018 15:17 |
| URI: |
https://eprints.nottingham.ac.uk/id/eprint/44241 |
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