Frequency of elemental events of intracellular Ca²⁺ dynamics

Thul, Ruediger and Falcke, Martin (2006) Frequency of elemental events of intracellular Ca²⁺ dynamics. Physical Review E, 73 . 061923. ISSN 1539-3755

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The dynamics of intracellular Ca²⁺ is driven by random events called Ca²⁺ puffs, in which Ca²⁺ is liberated from intracellular stores. We show that the emergence of Ca²⁺ puffs can be mapped to an escape process. The mean first passage times that correspond to the stochastic fraction of puff periods are computed from a novel master equation and two Fokker-Planck equations. Our results demonstrate that the mathematical modeling of Ca²⁺ puffs has to account for the discrete character of the Ca²⁺ release sites and does not permit a continuous description of the number of open channels.

Item Type:Article
Schools/Departments:Faculty of Science > School of Mathematical Sciences
ID Code:974
Deposited By:Thul, Dr Ruediger
Deposited On:19 Nov 2008 15:32
Last Modified:27 Jun 2011 11:16

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