DNA charge neutralisation by linear polymers II: reversible binding

Maltsev, Eugene and Wattis, Jonathan AD and Byrne, Helen M (2006) DNA charge neutralisation by linear polymers II: reversible binding. Physical Review E, 74 . 041918. ISSN 1539-3755

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We model the way in which polymers bind to DNA and neutralise its charged backbone by analysing the dynamics of the distribution of gaps along the DNA. We generalise existing theory for irreversible binding to construct new deterministic models which include polymer removal, movement along the DNA and allow for binding with overlaps. We show that reversible binding alters the capacity of the DNA for polymers by allowing the rearrangement of polymer positions over a longer timescale than when binding is irreversible. When the polymers do not overlap, allowing reversible binding increases the number of polymers adhered and hence the charge that the DNA can accommodate; in contrast, when overlaps occur, reversible binding reduces the amount of charge neutralised by the polymers.

Item Type:Article
Schools/Departments:Faculty of Science > School of Mathematical Sciences
ID Code:936
Deposited By:Wattis, Jonathan
Deposited On:15 Aug 2008 15:55
Last Modified:24 Jun 2011 15:36

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