Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach
Crossley, Nicolas A. and Sena, Emily S. and Goehler, Jos and Horn, Jannekke and van der Worp, H. Bart and Bath, Philip M.W. and Macleod, Malcolm R and Dirnagl, Ulrich (2008) Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach. Stroke, 39 . pp. 929-934. ISSN 1524-4628
Official URL: http://stroke.ahajournals.org/content/39/3/929
Background and Purpose: At least part of the failure in the transition from experimental to clinical studies in stroke has been attributed to the imprecision introduced by problems in the design of experimental stroke studies. Using a metaepidemiologic approach, we addressed the effect of randomization, blinding, and use of comorbid animals on the estimate of how effectively therapeutic interventions reduce infarct size.
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