Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis

Zachariou, Margarita and Dissanayake, Dilshani W N and Coombes, Stephen and Owen, Markus R. and Mason, Robert (2008) Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis. Cognitive Neurodynamics, 2 . pp. 159-170. ISSN 1871-4099

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Gating of sensory information can be assessed using an auditory conditioning-test paradigm which measures the reduction in the auditory evoked response to a test stimulus following an initial conditioning stimulus. Recording brainwaves from specific areas of the brain using multiple electrodes is helpful in the study of the neurobiology of sensory gating. In this paper, we use such technology to investigate the role of cannabinoids in sensory gating in the CA3 region of the rat hippocampus. Our experimental results show that application of the exogenous cannabinoid agonist WIN55,212-2 can abolish sensory gating. We have developed a phenomenological model of cannabinoid dynamics incorporated within a spiking neural network model of CA3 with synaptically interacting pyramidal and basket cells. Direct numerical simulations of this model suggest that

the basic mechanism for this effect can be traced to the suppression of inhibition of slow GABAB synapses. Furthermore, by working with a simpler mathematical firing rate model we are able to show the robustness of this mechanism for the abolition of sensory gating.

Item Type: Article
Keywords: sensory gating, cannabinoids, GABAB, firing rate models
Schools/Departments: University of Nottingham, UK > Faculty of Science > School of Mathematical Sciences
University of Nottingham, UK > Faculty of Medicine and Health Sciences > School of Life Sciences > School of Biomedical Sciences
Identification Number:
Depositing User: Coombes, Prof Stephen
Date Deposited: 08 Apr 2008 12:10
Last Modified: 26 Jun 2018 12:26

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