Preparation of potent and selective αvβ6 integrin inhibitors for the treatment of idiopathic pulmonary fibrosis and synthetic approaches towards the total synthesis of mescengricinTools Robinson, Henry Duncan (2021) Preparation of potent and selective αvβ6 integrin inhibitors for the treatment of idiopathic pulmonary fibrosis and synthetic approaches towards the total synthesis of mescengricin. PhD thesis, University of Nottingham.
AbstractIdiopathic pulmonary fibrosis (IPF) is a terminal illness characterised by excessive build-up of scar tissue within the lungs. Despite a relatively high incidence amongst the population, there are no currently available treatments that prolong the estimated lifespan of an affected individual beyond approximately six years.
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