Numerical simulation of circulating tumor cell separation in a dielectrophoresis based Y-Y shaped microfluidic device

Zhang, Xiangzhi and Xu, Xiawei and Ren, Yong and Yan, Yuying and Wu, Aiguo (2020) Numerical simulation of circulating tumor cell separation in a dielectrophoresis based Y-Y shaped microfluidic device. Separation and Purification Technology, 255 . p. 117343. ISSN 13835866

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Abstract

Efficient and effective separation of circulating tumor cells from biological samples to promote early diagnosis of cancer is important but challenging, especially for non-small cell lung cancer (NSCLC). In this article, a Y-Y shaped microfluidic device was designed to isolate NSCLC cells with a dielectrophoresis approach. Numerical simulations were conducted that the trajectories of cells were traced by solving the electric potential distribution and the flow field in a microchannel. The effects of inlet flow rate ratio of blood sample and buffer on separation performance were studied and optimized by the numerical investigation. Under optimal operating conditions, the separation efficiency can reach around 99%, which is achieved with 100 kHz AC, electrodes potential ranging from 1.6 V to 2.2 V, and flow rate ratio from 1.9 to 2.5. This study presents a potentially efficient, facile and low-cost route for circulating tumor cell separation.

Item Type: Article
Keywords: Microfluidics; Circulating tumor cells; Separation; Dielectrophoresis
Schools/Departments: University of Nottingham Ningbo China > Faculty of Science and Engineering
Identification Number: https://doi.org/10.1016/j.seppur.2020.117343
Depositing User: Zhou, Elsie
Date Deposited: 17 Sep 2020 06:16
Last Modified: 17 Sep 2020 06:16
URI: http://eprints.nottingham.ac.uk/id/eprint/63062

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