New chemistry to support the search for more effective opioids

Yang, Ruoyan (2020) New chemistry to support the search for more effective opioids. MSc(Res) thesis, University of Nottingham.

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Abstract

Herein is presented a synthesis route to obtain noroxymorphone, a vital intermediate in the manufacture of opioid medicines, using the major ingredient in opium – morphine as the starting material. Two steps of Albright-Goldman oxidation and the formation of diene are combined in one pot to enhance the efficiency of the whole route. The overall 14% yield is still impractical for industry. However, further optimization of Albright-Goldman oxidation can increase the yield to near 30% in total. Noroxymorphone is employed as a starting material to access new opioid derivatives by N-substitution or conjugate addition of amines onto electron-deficient alkenes.

Item Type: Thesis (University of Nottingham only) (MSc(Res))
Supervisors: Lam, Hon Wai
Keywords: Noroxymorphone, Opioid manufacture, Albright-Goldman oxidation
Subjects: R Medicine > RS Pharmacy and materia medica
Faculties/Schools: UK Campuses > Faculty of Science > School of Chemistry
Item ID: 60621
Depositing User: YANG, Ruoyan
Date Deposited: 28 Jul 2020 10:51
Last Modified: 28 Jul 2020 11:00
URI: http://eprints.nottingham.ac.uk/id/eprint/60621

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